PAPER Romero-Curiel A, López-Carpinteyro D, Gamboa C, de la Cruz F, Zamudio S, Flores G

Apamin induces plastic changes in hippocampal neurons in senile Sprague-Dawley rats.

Synapse. 2011 Oct;65(10):1062-72. PubMed: 21465567

PAPER Gupta-Rossi N, Ortica S, Meas-Yedid V, Heuss S, Moretti J, Olivo-Marin JC, Israël A

The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway.

J Biol Chem. 2011 May 27;286(21):18720-30. PubMed: 21464124

PAPER Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson DW, Bandyopadhyay U, Jiang Y, Pawlik M, Peterhoff CM, Yang AJ, Wilson DA, St George-Hyslop P, Westaway D, Mathews PM, Levy E, Cuervo AM, Nixon RA

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis.

Autophagy. 2011 Jul;7(7):788-9. PubMed: 21464620

Cornelius J Donnelly

Freelance Funding
Vero Beach, United States

PAPER Bartus RT, Herzog CD, Chu Y, Wilson A, Brown L, Siffert J, Johnson EM, Olanow CW, Mufson EJ, Kordower JH

Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains.

Mov Disord. 2011 Jan;26(1):27-36. PubMed: 21322017

PAPER Barhum Y, Gai-Castro S, Bahat-Stromza M, Barzilay R, Melamed E, Offen D

Intracerebroventricular transplantation of human mesenchymal stem cells induced to secrete neurotrophic factors attenuates clinical symptoms in a mouse model of multiple sclerosis.

J Mol Neurosci. 2010 May;41(1):129-37. PubMed: 19902385

PAPER Brundin P, Barker RA, Parmar M

Neural grafting in Parkinson's disease Problems and possibilities.

Prog Brain Res. 2010;184:265-94. PubMed: 20887880

PAPER Kirik D, Björklund A

Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results.

Brain. 2005 Jul;128(Pt 7):1478-9. PubMed: 15980119

Roberto Malinow on Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β.

COMMENT This study nicely examines potential signaling activated by β amyloid that could perturb LTP. The signaling identified can play multiple roles, so their exact participation in the effects of β amyloid needs to be elucidated. As targets for Alzheimer'

Barcelona: Is Parkinson’s Pathology Treatable?

CONFERENCE COVERAGE 2011-04-06 Conference Coverage Short answer: Not yet. But scientists are hammering away at the problem, and this series features progress reports on some experimental PD therapies. For Parkinson’s disease, unlike Alzheimer’s, physicians have numerous effective treat

Taos: Redox Redux—Putting the Oxidative Stress Theory to the Test

CONFERENCE COVERAGE 2011-04-06 Conference Coverage Suggesting that oxidative stress precipitates cell death in neurodegenerative disease is one thing; proving it is quite another. If seeing is believing, then researchers may have brought us one step closer. At Neurodegenerative Disease

PAPER Kruer MC, Hiken M, Gregory A, Malandrini A, Clark D, Hogarth P, Grafe M, Hayflick SJ, Woltjer RL

Novel histopathologic findings in molecularly-confirmed pantothenate kinase-associated neurodegeneration.

Brain. 2011 Apr;134(Pt 4):947-58. PubMed: 21459825

PAPER Hares K, Kemp K, Gray E, Scolding N, Wilkins A

Neurofilament dot blot assays: novel means of assessing axon viability in culture.

J Neurosci Methods. 2011 Jun 15;198(2):195-203. PubMed: 21459112

PAPER Palmer AM

The role of the blood brain barrier in neurodegenerative disorders and their treatment.

J Alzheimers Dis. 2011;24(4):643-56. PubMed: 21460432

PAPER Khodagholi F, Tusi SK

Stabilization of Nrf2 by tBHQ prevents LPS-induced apoptosis in differentiated PC12 cells.

Mol Cell Biochem. 2011 Aug;354(1-2):97-112. PubMed: 21461609