Magy Muminova

Uzbekistan

Martin Ingelsson on Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

COMMENT This is an interesting paper, indicating a marked elevation in the levels of various truncated and multimeric α-synuclein species in the endoplasmic reticulum (ER) from α-synuclein transgenic mice and PD patients. In mice, aggregated α-synuclein species a

Emma Jones on Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

COMMENT This paper examines toxic α-synuclein in the endoplasmic reticulum (ER) of a mouse model of synucleinopathy and in brain tissue from people with Parkinson’s disease using antibodies against α-synuclein oligomers and phosphorylated forms. Determining the n

dianne finch

MIT Knight Science Journalism
rockport, United States

karlaa karlaa

Romania

Researchers Pinpoint α-Synuclein Oligomers, Link Them to Cell Stress

RESEARCH NEWS 2012-03-19 Research News Large aggregates of misfolded α-synuclein form the characteristic Lewy bodies found in Parkinson's disease (PD) and other α-synucleinopathies. Smaller α-synuclein oligomers are suspected of being more toxic, but scientists have not been

Sanjukta Ghosh

United States

shih-ying wu

Taiwan, Province of China

Luis Fonseca

Cascais, Portugal

PAPER Lunau L, Mouridsen K, Rodell A, Ostergaard L, Nielsen JE, Isaacs A, Johannsen P,

Presymptomatic cerebral blood flow changes in CHMP2B mutation carriers of familial frontotemporal dementia (FTD-3), measured with MRI.

BMJ Open. 2012;2(2) PubMed: 22422914

PAPER Curtin D, Lynch T

New gene for ALS–FTD.

Mov Disord. 2012 Feb;27(2):202. PubMed: 22423382

PAPER Safar JG

Molecular pathogenesis of sporadic prion diseases in man.

Prion. 2012 Apr 1;6(2):108-15. PubMed: 22421210

PAPER Jia Y, Mu JC, Ackerman SL

Mutation of a U2 snRNA gene causes global disruption of alternative splicing and neurodegeneration.

Cell. 2012 Jan 20;148(1-2):296-308. PubMed: 22265417

PAPER Cui-Wang T, Hanus C, Cui T, Helton T, Bourne J, Watson D, Harris KM, Ehlers MD

Local zones of endoplasmic reticulum complexity confine cargo in neuronal dendrites.

Cell. 2012 Jan 20;148(1-2):309-21. PubMed: 22265418

PAPER Rodriguez-Rodriguez P, Fernandez E, Almeida A, Bolaños JP

Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration.

Cell Death Differ. 2012 Mar 16; PubMed: 22421967