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J20 (PDGF-APPSw,Ind)

RESEARCH MODELS Summary This popular mouse model overexpresses human APP with two mutations linked to familial Alzheimer's disease (the Swedish and Indiana mutations). Transgene expression is driven by the PDGF-β promoter and immunoreactivity is detected in neurons

A Protein-Based Study of Parkinsonism’s Incidence

RESEARCH NEWS 2013-05-24 Research News How often does parkinsonism loom in a population? Scientists revisiting this question published a new analysis of the incidence of Parkinson-related diseases in the May 20 JAMA Neurology online. Walter Rocca and colleagues at the Mayo Clinic

Finally, Therapies Targeting Huntingtin Poised for Clinic

COMMUNITY NEWS 2013-05-24 Community News Twenty years after the identification of the mutant gene that causes Huntington’s disease, scientists are ready to take therapies that target it into human trials. Studies in mouse models suggest that transiently squelching production of th

Aβ Fibrils Drive Oligomer Formation, New Model Suggests

RESEARCH NEWS 2013-05-24 Research News As attention shifts toward free-floating Aβ oligomers as the prime molecular culprits in Alzheimer’s disease, there is still plenty of confusion over the role of fibrillar amyloid, the stuff that sits in the disease’s hallmark brain plaques.

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