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331254 RESULTS

APOE Knock-out

RESEARCH MODELS Modification Details Inactivation of the endogenous mouse APOE by homologous recombination and insertion of a neomycin cassette. Other Phenotypes ApoE is undetectable in the plasma of these homozygous APOE knock-out mice. They are viable and appear health

APOE2 Targeted Replacement

RESEARCH MODELS Summary Targeted gene replacement was used to replace the endogenous murine APOE gene with the human APOE2 allele. In humans, the APOE2 allele is associated with decreased risk of Alzheimer's disease and an increased risk for type III hyperlipoprotei

APOE3 Targeted Replacement

RESEARCH MODELS Summary Gene targeting was used to replace the endogenouse murine APOE gene with the human APOE3 allele. On a standard diet, homozygous mice have normal cholesterol and triglyceride levels, but are more susceptible than wild-type animals to diet-induced a

APOE4 Targeted Replacement

RESEARCH MODELS Summary Gene targeting was used to replace the endogenous murine APOE gene with the human APOE4 allele. The mice are at increased risk of atherosclerosis compared with wild-type animals or mice expressing human APOE3. On a standard chow diet the mice have

Brain Connectivity Reveals Preclinical Alzheimer’s Disease

RESEARCH NEWS 2013-08-29 Research News Connections in the brain’s default mode network (DMN) begin to falter years before the onset of clinical symptoms in both sporadic and familial Alzheimer’s disease (AD), according to two new papers. Researchers led by Beau Ances at Washingto

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