PAPER Gao L, Zeng XN, Guo HM, Wu XM, Chen HJ, Di RK, Wu Y
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PAPER Jicha GA
Medical management of frontotemporal dementias: the importance of the caregiver in symptom assessment and guidance of treatment strategies.
J Mol Neurosci. 2011 Nov;45(3):713-23. PubMed: 21647712PAPER Wyss DF, Wang YS, Eaton HL, Strickland C, Voigt JH, Zhu Z, Stamford AW
Combining NMR and X-ray Crystallography in Fragment-Based Drug Discovery: Discovery of Highly Potent and Selective BACE-1 Inhibitors.
Top Curr Chem. 2011 Jun 7; PubMed: 21647837PAPER Midi I, Doǧan M, Pata YS, Kocak I, Mollahasanoglu A, Tuncer N
The effects of verbal reaction time in Alzheimer's disease.
Laryngoscope. 2011 Jul;121(7):1495-503. PubMed: 21647891PAPER Su C, Underwood W, Rybalchenko N, Singh M
ERK1/2 and ERK5 have distinct roles in the regulation of brain-derived neurotrophic factor expression.
J Neurosci Res. 2011 Oct;89(10):1542-50. PubMed: 21647938PAPER Lyons MK
Deep brain stimulation: current and future clinical applications.
Mayo Clin Proc. 2011 Jul;86(7):662-72. PubMed: 21646303PAPER Brown PJ, Devanand DP, Liu X, Caccappolo E,
Functional impairment in elderly patients with mild cognitive impairment and mild Alzheimer disease.
Arch Gen Psychiatry. 2011 Jun;68(6):617-26. PubMed: 21646578PAPER Emery VO
Alzheimer disease: are we intervening too late? Pro.
J Neural Transm. 2011 Sep;118(9):1361-78. PubMed: 21647682Aldo Pagano on RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neurodegeneration.
COMMENT In agreement with Christian Haass, I recommend prudence in linking, unequivocally, the forced expression of 38A ncRNA to the pathological manifestations of AD. We must be cautious in ascribing to its over-synthesis a causative mechanism of AD onset. In th
Hui Zheng on Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.
COMMENT This paper presents two interesting findings. One is that expression of APP in human embryonic stem cells (hESCs) robustly promotes neuronal differentiation. The other is that this effect is mediated by soluble APP (sAPP) and that sAPPβ is more potent tha
Lars Nilsson on Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.
COMMENT The study by Winton et al. is a well-designed study that provides important new information on a frequently used animal model of Alzheimer’s disease. However, based on the results presented, I would be cautious to conclude that intraneuronal Aβ accumulati
Se Hoon Choi
Massachusetts General HospitalCharlestown, United States
PAPER Silveri MC, Ciccarelli N, Cappa A
Unilateral spatial neglect in degenerative brain pathology.
Neuropsychology. 2011 Sep;25(5):554-66. PubMed: 21639641PAPER Tsujimoto M, Senda J, Ishihara T, Niimi Y, Kawai Y, Atsuta N, Watanabe H, Tanaka F, Naganawa S, Sobue G
Behavioral changes in early ALS correlate with voxel-based morphometry and diffusion tensor imaging.
J Neurol Sci. 2011 Aug 15;307(1-2):34-40. PubMed: 21641004PAPER Martin I, Dawson VL, Dawson TM
Recent advances in the genetics of Parkinson's disease.
Annu Rev Genomics Hum Genet. 2011 Sep 22;12:301-25. PubMed: 21639795Current Filters
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