PAPER Ducharme N, Banks WA, Morley JE, Robinson SM, Niehoff ML, Mattern C, Farr SA

Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration.

Eur J Pharmacol. 2010 Sep 1;641(2-3):128-34. PubMed: 20570588

PAPER Meulenbroek O, Rijpkema M, Kessels RP, Rikkert MG, Fernández G

Autobiographical memory retrieval in patients with Alzheimer's disease.

Neuroimage. 2010 Oct 15;53(1):331-40. PubMed: 20570740

PAPER Rodríguez-Rodríguez E, Vázquez-Higuera JL, Sánchez-Juan P, Mateo I, Pozueta A, Martínez-García A, Frank A, Valdivieso F, Berciano J, Bullido MJ, Combarros O

Epistasis between intracellular cholesterol trafficking-related genes (NPC1 and ABCA1) and Alzheimer's disease risk.

J Alzheimers Dis. 2010;21(2):619-25. PubMed: 20571217

PAPER Li RC, Guo SZ, Lee SK, Gozal D

Neuroglobin protects neurons against oxidative stress in global ischemia.

J Cereb Blood Flow Metab. 2010 Nov;30(11):1874-82. PubMed: 20571522

PAPER Mielke MM, Lyketsos CG

Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?

Neuromolecular Med. 2010 Dec;12(4):331-40. PubMed: 20571935

Benjamin Wolozin on Law and Disorder—APPswe Patent Suits Raise Ruckus Again

COMMENT The report by Esther Landhuis and Gabrielle Strobel reflects the inherent intellectual and financial turbulence that evolves when advancing technology interfaces with the patent system and commercial system. First, let’s examine the patent issues. It is c

PAPER Pidsley R, Dempster EL, Mill J

Brain weight in males is correlated with DNA methylation at IGF2.

Mol Psychiatry. 2010 Sep;15(9):880-1. PubMed: 20010889

PAPER Tycko B

Mapping allele-specific DNA methylation: a new tool for maximizing information from GWAS.

Am J Hum Genet. 2010 Feb 12;86(2):109-12. PubMed: 20159108

PAPER Kerkel K, Spadola A, Yuan E, Kosek J, Jiang L, Hod E, Li K, Murty VV, Schupf N, Vilain E, Morris M, Haghighi F, Tycko B

Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation.

Nat Genet. 2008 Jul;40(7):904-8. PubMed: 18568024

PAPER Lister R, Pelizzola M, Dowen RH, Hawkins RD, Hon G, Tonti-Filippini J, Nery JR, Lee L, Ye Z, Ngo QM, Edsall L, Antosiewicz-Bourget J, Stewart R, Ruotti V, Millar AH, Thomson JA, Ren B, Ecker JR

Human DNA methylomes at base resolution show widespread epigenomic differences.

Nature. 2009 Nov 19;462(7271):315-22. PubMed: 19829295

Martin Forde on The role of amyloid-beta derived diffusible ligands (ADDLs) in Alzheimer's disease.

COMMENT Catalano et al. hypothesize that disruption of fibrils could result in an increase of soluble Aβ oligomers. I want to test this hypothesis in vivo, specifically that disrupting fibrils leads to increases in ADDLs that correlates with cognitive deficits in

Ralph Nixon on Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations.

COMMENT Reply to comment by Tony Wyss-Coray Since its very early descriptions, autophagy has been defined as the lysosomal digestion of a cell’s own cytoplasmic material and not simply the sequestration of these components. Implied by this definition, and general

Ana Maria Cuervo

Albert Einstein College of Medicine
Bronx, United States

α-Synuclein (Syn211)

ANTIBODY monoclonal Syn211 manufacturer Cat# S5566<br />Reference: <br /><a href="/papers/distinct-region-specific-alpha-synuclein-oligomers-a53t-transgenic-mice-implications" target="_new">Tsika, 2010</a> immunogen = re

PAPER Oh J, McCloskey MA, Blong CC, Bendickson L, Nilsen-Hamilton M, Sakaguchi DS

Astrocyte-derived interleukin-6 promotes specific neuronal differentiation of neural progenitor cells from adult hippocampus.

J Neurosci Res. 2010 Oct;88(13):2798-809. PubMed: 20568291