PAPER Hook G, Hook V, Kindy M
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PAPER Hui Y, Wang D, Li W, Zhang L, Jin J, Ma N, Zhou L, Nakajima O, Zhao W, Gao X
Long-term overexpression of heme oxygenase 1 promotes tau aggregation in mouse brain by inducing tau phosphorylation.
J Alzheimers Dis. 2011;26(2):299-313. PubMed: 21613741PAPER Takasaki K, Uchida K, Fujikawa R, Nogami A, Nakamura K, Kawasaki C, Yamaguchi K, Morita M, Morishita K, Kubota K, Katsurabayashi S, Mishima K, Fujiwara M, Iwasaki K
Neuroprotective effects of citidine-5-diphosphocholine on impaired spatial memory in a rat model of cerebrovascular dementia.
J Pharmacol Sci. 2011;116(2):232-7. PubMed: 21613753PAPER Hernández-Ortega K, Quiroz-Baez R, Arias C
Cell cycle reactivation in mature neurons: a link with brain plasticity, neuronal injury and neurodegenerative diseases?
Neurosci Bull. 2011 Jun;27(3):185-96. PubMed: 21614101PAPER Quaid KA
Genetic counseling for frontotemporal dementias.
J Mol Neurosci. 2011 Nov;45(3):706-9. PubMed: 21614537PAPER Westlye ET, Lundervold A, Rootwelt H, Lundervold AJ, Westlye LT
Increased hippocampal default mode synchronization during rest in middle-aged and elderly APOE ε4 carriers: relationships with memory performance.
J Neurosci. 2011 May 25;31(21):7775-83. PubMed: 21613490PAPER van de Pol L, Gertz HJ, Scheltens P, Wolf H
Hippocampal atrophy in subcortical vascular dementia.
Neurodegener Dis. 2011;8(6):465-9. PubMed: 21613775PAPER Winton MJ, Lee EB, Sun E, Wong MM, Leight S, Zhang B, Trojanowski JQ, Lee VM
Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration.
J Neurosci. 2011 May 25;31(21):7691-9. PubMed: 21613482PAPER Xiao F, Li XG, Zhang XY, Hou JD, Lin LF, Gao Q, Luo HM
Combined administration of D-galactose and aluminium induces Alzheimer-like lesions in brain.
Neurosci Bull. 2011 Jun;27(3):143-55. PubMed: 21614097PAPER Nixon RA, Cataldo AM, Paskevich PA, Hamilton DJ, Wheelock TR, Kanaley-Andrews L
The lysosomal system in neurons. Involvement at multiple stages of Alzheimer's disease pathogenesis.
Ann N Y Acad Sci. 1992 Dec 31;674:65-88. PubMed: 1288372PAPER Lee S, Sato Y, Nixon RA
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy.
J Neurosci. 2011 May 25;31(21):7817-30. PubMed: 21613495Barbara Tate on Smuggling Antibodies to BACE Across the Blood-Brain Barrier
COMMENT This pair of papers describes the efficacy of an antibody approach to inhibiting BACE1 activity, as well as an ingenious method for getting higher concentrations of therapeutic antibody into the brain. Passive immunization with a highly specific antibody
Dave Morgan on Smuggling Antibodies to BACE Across the Blood-Brain Barrier
COMMENT Here is my quick reaction to these intriguing papers, without the benefit of having had time to fully consider their impact. BACE1 is an intracellular target. This raises a level of challenge for antibody action beyond the blood-brain barrier, though it i
PAPER Luo X, Prior M, He W, Hu X, Tang X, Shen W, Yadav S, Kiryu-Seo S, Miller R, Trapp BD, Yan R
Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination.
J Biol Chem. 2011 Jul 8;286(27):23967-74. PubMed: 21576249PAPER Yu YJ, Zhang Y, Kenrick M, Hoyte K, Luk W, Lu Y, Atwal J, Elliott JM, Prabhu S, Watts RJ, Dennis MS
Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target.
Sci Transl Med. 2011 May 25;3(84):84ra44. PubMed: 21613623Current Filters
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