330889 RESULTS
RESEARCH MODELS Summary These mice lack PSEN2; no gene product (mRNA or protein) is detected by Northern or Western blot analysis. Homozygous mice are viable, born at expected Mendelian frequency, and fertile. They are normal in growth and size and do not display any gro
RESEARCH MODELS Summary These mice were generated along with an APP YAC line and crossed to compare the phenotypes of the single transgenics with the double transgenic. The PS-1 YAC mice are viable and fertile as hemizygotes but not viable as homozygotes. They express hu
RESEARCH MODELS Summary These floxed mice can be used to generate animals with conditional knock-out of presenilin-1. They can be crossed with strains expressing Cre recombinase to target the gene deletion to specific cell types, such as postnatal neurons (see The Jackso
CONFERENCE COVERAGE SERIES Cerebrospinal Fluid Tau Climbs in Aβ Mouse Models Coverage Denial For Amyloid Scans Riles Alzheimer’s Community Pooled GWAS Reveals New Alzheimer’s Genes and Pathways Are Subtle Memory Concerns a Sign of Future Dementia? Clinical Trials Roundup: Four Hits
RESEARCH NEWS 2013-08-16 Research News Specific neurons may degenerate in amyotrophic lateral sclerosis and frontotemporal dementia because they rely heavily on the RNA-binding protein FUS to manage messenger RNAa. This conclusion comes from a paper in the August 8 Scientific Rep
PAPER Kwok CT, Morris A, de Belleroche JS
PAPER Chen S, Sayana P, Zhang X, Le W
PAPER Ramirez S, Liu X, Lin PA, Suh J, Pignatelli M, Redondo RL, Ryan TJ, Tonegawa S
PAPER Fondell E, Fitzgerald KC, Falcone GJ, O'Reilly EJ, Ascherio A
PAPER Matrone C
PAPER Sun ZL, Feng DF
PAPER Stern Y
PAPER van de Glind EM, van Enst WA, van Munster BC, Olde Rikkert MG, Scheltens P, Scholten RJ, Hooft L
PAPER Small DH, Hu Y, Bolós M, Dawkins E, Foa L, Young KM
PAPER Soloway AH, Soloway PD, Warner VD
No filters selected
