Parvathi Rudrabhatla

Research fellow
Bethesda, United States

Lei Feng on A Boost for Waning DNA Tags Fixes Age-Related Memory Loss in Mice

COMMENT This is very interesting. I am wondering how to relate those findings to the roles of folate in brain function and cognitive aging in humans. Folate provides one carbon group to methylate DNA and other substrates. In population-based studies, low folate h

PAPER Feng L

Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline.

Am J Clin Nutr. 2012 May;95(5):1289-90; author reply 1290. PubMed: 22523150

PAPER Feng L, Ng TP, Chuah L, Niti M, Kua EH

Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore Longitudinal Ageing Study.

Am J Clin Nutr. 2006 Dec;84(6):1506-12. PubMed: 17158436

Roberta Diaz Brinton on Alzheimer’s disease: the new promise.

COMMENT This comment by Stephen Strittmatter is based on two critical publications which I highly recommend reading (Talbot et al., 2012; Bomfim et al., 2012). 0 rbrinton Demonstrated brain insulin resistance in Alzheimer's disease patients is associated wit

Matthew Zabel on Protective APP Mutation Found—Supports Amyloid Hypothesis

COMMENT New APP Mutation Does Not Advance the Amyloid Hypothesis Debate In response to the question, Does β amyloid accumulation drive Alzheimer’s disease?, the answer is “most likely no,” and the new data presented by Jonsson et al. does not change that answer.

Luciano D'Adamio on Protective APP Mutation Found—Supports Amyloid Hypothesis

COMMENT I agree with the comments underlying the importance of this paper, which supports the pathogenic role of APP processing by BACE in sporadic AD. As noted in many comments, these findings also suggest that inhibition of BACE processing of APP will be a bene

Nahuai Badiola

Institute for Research in Biomedicine
Barcelona, Spain

Experimental α7 Agonist Meets Cognitive and Clinical Endpoints

CONFERENCE COVERAGE 2012-07-18 Conference Coverage In Alzheimer’s disease drug development, how often does it happen that a large phase 2b trial of an experimental medicine cleanly meets both primary and secondary endpoints as set out in the protocol? Today, at the Alzheimer’s Associat

PAPER Premi E, Garibotto V, Alberici A, Paghera B, Giubbini R, Padovani A, Borroni B

Nature versus Nurture in Frontotemporal Lobar Degeneration: the Interaction of Genetic Background and Education on Brain Damage.

Dement Geriatr Cogn Disord. 2012;33(6):372-8. PubMed: 22797130

PAPER Knight LS, Wenzel HJ, Schwartzkroin PA

Inhibition and interneuron distribution in the dentate gyrus of p35 knockout mice.

Epilepsia. 2012 Jun;53 Suppl 1:161-70. PubMed: 22612821

PAPER Yang M, Kim JS, Kim J, Jang S, Kim SH, Kim JC, Shin T, Wang H, Moon C

Acute treatment with methotrexate induces hippocampal dysfunction in a mouse model of breast cancer.

Brain Res Bull. 2012 Oct 1;89(1-2):50-6. PubMed: 22796103

PAPER Constant JP, Fraley GS, Forbes E, Hallas BH, Leheste JR, Torres G

Resveratrol protects neurons from cannulae implantation injury: Implications for deep brain stimulation.

Neuroscience. 2012 Oct 11;222:333-42. PubMed: 22796077

PAPER Selenica ML, Brownlow M, Jimenez JP, Lee DC, Pena G, Dickey CA, Gordon MN, Morgan D

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy.

Neurodegener Dis. 2012 Jul 10; PubMed: 22796753

PAPER Lang L, Kurnik M, Danielsson J, Oliveberg M

Fibrillation precursor of superoxide dismutase 1 revealed by gradual tuning of the protein-folding equilibrium.

Proc Natl Acad Sci U S A. 2012 Jul 13; PubMed: 22797895