PAPER Jarraya B, Boulet S, Ralph GS, Jan C, Bonvento G, Azzouz M, Miskin JE, Shin M, Delzescaux T, Drouot X, Hérard AS, Day DM, Brouillet E, Kingsman SM, Hantraye P, Mitrophanous KA, Mazarakis ND, Palfi S
SEARCH RESULTS
330988 RESULTS
PAPER Muramatsu S, Fujimoto K, Kato S, Mizukami H, Asari S, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K, Nakano I
A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease.
Mol Ther. 2010 Sep;18(9):1731-5. Epub 2010 Jul 6 PubMed: 20606642Jeffrey Jasper on Transcription Factor Nourishes Neuron-Muscle Pair in ALS Model
COMMENT This is an interesting manuscript. The authors demonstrated that transgenic overexpression of ATF3 in motor neurons of SOD1 mice promoted motor neuron survival and maintained axonal integrity and neuromuscular junction (NMJ) innervations. They found in AT
Transcription Factor Nourishes Neuron-Muscle Pair in ALS Model
RESEARCH NEWS 2014-01-17 Research News A gene that was once considered a simple cell stress marker turns out to be a short-term savior for motor neurons in a mouse model of amyotrophic lateral sclerosis. In the January 13 Proceedings of the National Academy of Sciences online, re
PAPER Seijffers R, Mills CD, Woolf CJ
ATF3 increases the intrinsic growth state of DRG neurons to enhance peripheral nerve regeneration.
J Neurosci. 2007 Jul 25;27(30):7911-20. PubMed: 17652582PAPER Seijffers R, Allchorne AJ, Woolf CJ
The transcription factor ATF-3 promotes neurite outgrowth.
Mol Cell Neurosci. 2006 May-Jun;32(1-2):143-54. Epub 2006 May 19 PubMed: 16713293Raymond Bartus on Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.
COMMENT The study by Palfi et al. is a welcome addition to the literature, reporting the results of 15 Parkinson’s patients treated with a lenti-viral vector intended to enhance dopamine function in the terminal field of the degenerating dopamine neurons. The tri
Raymond Bartus
RTBioconsultantsSan Diego, United States
Barbara Tate on GSAP Revisited: Does It Really Play a Role in Processing Aβ?
COMMENT The irreproducibility of the literature data also impacts the speed and cost of discovering new therapies. The commitment to start an industry drug-discovery program is an expensive proposition, and risky if based only on the scientific literature because
Laurel Beckett on Japanese ADNI Called to Defend Its Data Handling
COMMENT I know about the J-ADNI allegations mostly through our colleagues in Japan. My first impression, at a distance and through several filters, is that the allegations represent a misinterpretation of a standard data-checking process that, as such things do,
Takashi Asada on Japanese ADNI Called to Defend Its Data Handling
COMMENT I am pleased to have this opportunity to clear up this situation. First, allegations of falsification of data made by me are themselves false. I conducted a press conference on January 10, where I stated that large-scale data sets are susceptible to error
Japanese ADNI Called to Defend Its Data Handling
COMMUNITY NEWS 2014-01-17 Community News Allegations of falsified clinical data rocked the Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI) on January 10. An unidentified project researcher made the claims to the Japanese health ministry, which in turn questioned J-AD
Laurel Beckett
University of California, Davis, School of MedicineDavis
Jeffrey Jasper
CytokineticsSouth San Francisco, United States
Nicotinic Acetylcholine Receptors 2014
CONFERENCE 2014-07-23 00:00:00-2014-07-26 00:00:00 Churchill College, Cambridge, U.K. 23 July 2014 to 26 July 2014 This is the third Wellcome Trust conference on nicotinic acetylcholine receptors, following highly successful meetings in 2008 and 2011. nAChRs remain a focus of innovative research: from hig
Current Filters
No filters selected