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Probe Shines a Light on γ-Secretase Inhibitor’s Broad Reach

RESEARCH NEWS 2017-01-14 Research News Efforts to derail the production of Aβ42 by targeting the enzyme that produces it, γ-secretase, have been complicated by the secretase’s complexity and promiscuity for substrates. In a paper published in Cell Chemical Biology on January 5, ...

NINDS Exploratory Clinical Trials (R01)

GRANT Friday, January 13, 2017- 16:15 National Institute of Neurological Disorders and Stroke March 21, 2017, then Standard dates apply, by 5 p.m. local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity ...

Forming FUS Droplets with a Flash of Light

RESEARCH NEWS 2017-01-13 Research News FUS, HNRNPA1, and other RNA-binding proteins implicated in ALS and other neurodegenerative diseases have a floppy tail. These intrinsically disordered regions (IDRs) allow proteins to undergo liquid phase separation and form liquid droplets. ...

Antibodies Co-Opt Anti-Microbial Response to Clear Intraneuronal Tau

RESEARCH NEWS 2017-01-13 Research News Scientists are developing therapeutic antibodies against pathologic forms of tau, but questions remain about how these antibodies eliminate the protein. While some studies suggest they clear extracellular tau aggregates, a paper in the ...

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