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PAPER Fujimaki N, Kitamura F, Takeuchi H
Pro-Oxidant Copper-Binding Mode of the Apo Form of ALS-Linked SOD1 Mutant H43R Denatured at Physiological Temperature.
Biochemistry. 2013 Jul 22; PubMed: 23837654PAPER Moujalled D, James JL, Parker SJ, Lidgerwood GE, Duncan C, Meyerowitz J, Nonaka T, Hasegawa M, Kanninen KM, Grubman A, Liddell JR, Crouch PJ, White AR
Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.
PLoS One. 2013;8(6):e67433. PubMed: 23840699PAPER Georgy GS, Nassar NN, Mansour HA, Abdallah DM
Cerebrolysin Ameloriates Cognitive Deficits in Type III Diabetic Rats.
PLoS One. 2013;8(6):e64847. PubMed: 23840309PAPER Bezprozvanny I
Presenilins and calcium signaling-systems biology to the rescue.
Sci Signal. 2013 Jul 9;6(283):pe24. PubMed: 23838181Jean Georges
Alzheimer EuropeUnited States
PAPER Miller R, Ito K, Lalovic B
Models for event-driven data: longitudinal daily adverse event and dropout.
J Clin Pharmacol. 2010 Sep;50(9 Suppl):58S-62S. PubMed: 20881219PAPER Romanelli MF, Morris JC, Ashkin K, Coben LA
Advanced Alzheimer's disease is a risk factor for late-onset seizures.
Arch Neurol. 1990 Aug;47(8):847-50. PubMed: 2375689TDP-43
ALZPEDIA In 2006, TAR DNA-binding protein 43 (TDP-43) was identified as the cardinal protein in the most common subtypes of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Together with the 2006 discovery of progranulin, this was a major bre
TREM2
ALZPEDIA Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor of the innate immune system expressed on microglia, macrophages, dendritic cells, and osteoclasts. TREM2 is a member of the immunoglobulin superfamily. Endogenous ligands of this recep
PICALM
ALZPEDIA PICALM is an accessory protein in the endocytic pathway. Ubiquitously expressed, PICALM binds to clathrin and its adaptor proteins, which together regulate the formation of the clathrin lattice during endocytosis. PICALM was identified in one of the first
Complement Receptor 1 (CR1)
ALZPEDIA The complement receptor 1 (CR1) gene encodes a transmembrane glycoprotein that functions in the innate immune system. CR1 is expressed on blood cells and microglia. As a receptor for the complement components C3b and C4b, CR1 helps regulate activation of
Anouchka Seesaghur
Decision Resources Group
Clusterin
ALZPEDIA Clusterin is a highly conserved glycoprotein that functions primarily as an extracellular chaperone. Multiple large genome-wide association studies (GWAS) have uncovered clusterin variants that strongly associate with late-onset Alzheimer’s disease, earni
APOE
ALZPEDIA Apolipoprotein E is a secreted apolipoprotein involved in lipid metabolism. It complexes with lipids to form lipoprotein particles that transport cholesterol and triglycerides via the bloodstream and facilitate the transfer of cholesterol and phospholipid
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