RESEARCH NEWS 2015-04-17 Research News More than a year ago, researchers identified variants in phospholipase D3 (PLD3) as risk factors for Alzheimer’s disease. First found in two families and then confirmed in several larger cohorts, the variants reportedly doubled the risk of ...
Amy Nelson, Berislav Zlokovic on BMI and risk of dementia in two million people over two decades: a retrospective cohort study.
COMMENT It is becoming more appreciated that damage to microvessels and the blood-brain barrier may kick-start Alzheimer’s disease (AD) progression. In fact, ailments affecting the neurovasculature, such as cardiovascular disease, hypertension, stroke, and ...
COMMENT MicroRNA expression profiling studies of the AD brain have yielded invaluable information about microRNAs whose expression consistently differs between healthy and diseased CNS. These findings not only shed light on regulatory mechanisms possibly ...
PAPER Shaltiel G, Hanan M, Wolf Y, Barbash S, Kovalev E, Shoham S, Soreq H
Hippocampal microRNA-132 mediates stress-inducible cognitive deficits through its acetylcholinesterase target.Brain Struct Funct. 2013 Jan;218(1):59-72. Epub 2012 Jan 14 PubMed: 22246100
PAPER Mukherji S, Ebert MS, Zheng GX, Tsang JS, Sharp PA, van Oudenaarden A21857679
PAPER Chen YW, Song S, Weng R, Verma P, Kugler JM, Buescher M, Rouam S, Cohen SM
Systematic study of Drosophila microRNA functions using a collection of targeted knockout mutations.Dev Cell. 2014 Dec 22;31(6):784-800. PubMed: 25535920
Bjørn Heine Strand on BMI and risk of dementia in two million people over two decades: a retrospective cohort study.
COMMENT The increased dementia risk associated with underweight in midlife fits well with our own unpublished results, which have been puzzled about. Our intention has been to publish a separate paper on this, where we include BMI in early midlife, late midlife, ...
Norwegian Institute of Public HealthOslo, Norway
Warminster, United States
PAPER Gilbert C, Wilcock J, Thuné-Boyle I, Iliffe S25872786
PAPER Chiatti C, Furneri G, Rimland JM, Demma F, Bonfranceschi F, Cassetta L, Masera F, Cherubini A, Corsonello A, Lattanzio F
The economic impact of moderate stage Alzheimer's disease in Italy: evidence from the UP-TECH randomized trial.Int Psychogeriatr. 2015 Apr 15;:1-10. PubMed: 25874654
PAPER Piersma D, de Waard D, Davidse R, Tucha O, Brouwer W25874501
PAPER Arcand M
End-of-life issues in advanced dementia: Part 2: management of poor nutritional intake, dehydration, and pneumonia.Can Fam Physician. 2015 Apr;61(4):337-341. PubMed: 25873701
No filters selected