PAPER Hsu CY, Huang CC, Chan WL, Huang PH, Chiang CH, Chen TJ, Chung CM, Lin SJ, Chen JW, Leu HB
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PAPER Chen Y, Liang Z, Blanchard J, Dai CL, Sun S, Lee MH, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX
A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer's Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse).
Mol Neurobiol. 2012 Nov 14; PubMed: 23150171PAPER Marques S, Outeiro TF
Epigenetics in Parkinson's and Alzheimer's diseases.
Subcell Biochem. 2012;61:507-25. PubMed: 23150265PAPER Benoit ME, Hernandez MX, Dinh ML, Benavente F, Vasquez O, Tenner AJ
C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity.
J Biol Chem. 2013 Jan 4;288(1):654-65. PubMed: 23150673PAPER Ortiz JE, Berkov S, Pigni NB, Theoduloz C, Roitman G, Tapia A, Bastida J, Feresin GE
Wild Argentinian Amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids.
Molecules. 2012;17(11):13473-82. PubMed: 23149565PAPER Landau SM, Doraiswamy PM
The Biology of Alzheimer Disease.
JAMA. 2012 Nov 14;308(18):1925-1926. PubMed: 23150013Terrence Town on Enter the New Alzheimer’s Gene: TREM2 Variant Triples Risk
COMMENT The present work can be viewed as key support for the neuroinflammation hypothesis of Alzheimer’s disease. In my mind, at least, it dovetails well with earlier work demonstrating genomewide association between another microglial proinflammatory gene, comp
Leslie Shaw on A selected reaction monitoring (SRM)-based method for absolute quantification of Aβ38, Aβ40, and Aβ42 in cerebrospinal fluid of Alzheimer's disease patients and healthy controls.
COMMENT This paper describes development of a direct selected reaction monitoring (SRM) mass spectrometric method for measuring Aβ42, Aβ40, and Aβ38. This technique avoids using antibodies to capture Aβ peptides and their possible bias due to affinity and epitope
PAPER Leuchter AF, Newton TF, Cook IA, Walter DO, Rosenberg-Thompson S, Lachenbruch PA
Changes in brain functional connectivity in Alzheimer-type and multi-infarct dementia.
Brain. 1992 Oct;115 ( Pt 5):1543-61. PubMed: 1422803PAPER Cook IA, Leuchter AF
Synaptic dysfunction in Alzheimer's disease: clinical assessment using quantitative EEG.
Behav Brain Res. 1996 Jun;78(1):15-23. PubMed: 8793033PAPER Leuchter AF, Cook IA, Hunter AM, Cai C, Horvath S
Resting-state quantitative electroencephalography reveals increased neurophysiologic connectivity in depression.
PLoS One. 2012;7(2):e32508. PubMed: 22384265PAPER , Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT, McVean GA
An integrated map of genetic variation from 1,092 human genomes.
Nature. 2012 Nov 1;491(7422):56-65. PubMed: 23128226Biomarker Progress? Picking the New, Better Measuring the Old
RESEARCH NEWS 2012-11-15 Research News Even as Alzheimer’s disease biomarkers are wending their way through a lengthy standardization and qualification process, individual labs are experimenting with deploying them toward the next challenge, that is, to improve the differential d
CTAD: EEG Gains Luster as More Trials Incorporate Biomarkers
CONFERENCE COVERAGE 2012-11-15 Conference Coverage The 5th Clinical Trials in Alzheimer’s Disease conference, held 29-31 October in Monaco, showcased the field’s pressing need for biomarkers as outcome measures. Several talks focused on electroencephalography (EEG), a somewhat overlook
Contest Winners Offer Solutions for Tracking ALS
RESEARCH NEWS 2012-11-15 Research News The nonprofit Prize4Life announced yesterday that it would reward two scientific teams $20,000 each for their proposed solutions to track the progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that causes muscle
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