PAPER Lo RY, Hubbard AE, Shaw LM, Trojanowski JQ, Petersen RC, Aisen PS, Weiner MW, Jagust WJ,
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329939 RESULTS
PAPER Bayer-Carter JL, Green PS, Montine TJ, Vanfossen B, Baker LD, Watson GS, Bonner LM, Callaghan M, Leverenz JB, Walter BK, Tsai E, Plymate SR, Postupna N, Wilkinson CW, Zhang J, Lampe J, Kahn SE, Craft S
Diet intervention and cerebrospinal fluid biomarkers in amnestic mild cognitive impairment.
Arch Neurol. 2011 Jun;68(6):743-52. PubMed: 21670398PAPER Nelson LD, Siddarth P, Kepe V, Scheibel KE, Huang SC, Barrio JR, Small GW
Positron emission tomography of brain β-amyloid and τ levels in adults with Down syndrome.
Arch Neurol. 2011 Jun;68(6):768-74. PubMed: 21670401PAPER Hachinski V
Stroke and Alzheimer disease: fellow travelers or partners in crime?
Arch Neurol. 2011 Jun;68(6):797-8. PubMed: 21670403PAPER Revel FG, Moreau JL, Gainetdinov RR, Bradaia A, Sotnikova TD, Mory R, Durkin S, Zbinden KG, Norcross R, Meyer CA, Metzler V, Chaboz S, Ozmen L, Trube G, Pouzet B, Bettler B, Caron MG, Wettstein JG, Hoener MC
TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity.
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8485-90. PubMed: 21525407PAPER Attwood BK, Bourgognon JM, Patel S, Mucha M, Schiavon E, Skrzypiec AE, Young KW, Shiosaka S, Korostynski M, Piechota M, Przewlocki R, Pawlak R
Neuropsin cleaves EphB2 in the amygdala to control anxiety.
Nature. 2011 May 19;473(7347):372-5. PubMed: 21508957PAPER Wolinsky TD, Swanson CJ, Smith KE, Zhong H, Borowsky B, Seeman P, Branchek T, Gerald CP
The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia.
Genes Brain Behav. 2007 Oct;6(7):628-39. PubMed: 17212650PAPER Segman RH, Shefi N, Goltser-Dubner T, Friedman N, Kaminski N, Shalev AY
Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors.
Mol Psychiatry. 2005 May;10(5):500-13, 425. PubMed: 15685253PAPER Burchett SA, Hicks TP
The mysterious trace amines: protean neuromodulators of synaptic transmission in mammalian brain.
Prog Neurobiol. 2006 Aug;79(5-6):223-46. PubMed: 16962229PAPER Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C
Trace amines: identification of a family of mammalian G protein-coupled receptors.
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):8966-71. PubMed: 11459929Christian Hoelscher on Insulin suppresses the expression of amyloid precursor protein, presenilins, and glycogen synthase kinase-3beta in peripheral blood mononuclear cells.
COMMENT This is a most interesting finding. One important observation after gastric bypass surgery is that the patients are almost immediately relieved from being diabetic. This is linked to increased GLP-1 release (see, e.g., Morínigo et al., 2006). It is not un
PAPER Morínigo R, Moizé V, Musri M, Lacy AM, Navarro S, Marín JL, Delgado S, Casamitjana R, Vidal J
Glucagon-like peptide-1, peptide YY, hunger, and satiety after gastric bypass surgery in morbidly obese subjects.
J Clin Endocrinol Metab. 2006 May;91(5):1735-40. PubMed: 16478824Ruth Itzhaki on Herpes simplex virus type I induces the accumulation of intracellular β-amyloid in autophagic compartments and the inhibition of the non-amyloidogenic pathway in human neuroblastoma cells.
COMMENT Three more papers supporting the concept of a viral involvement in AD have recently been published. Santana et al. (1) found, as we did, that Aβ accumulation occurred in HSV1-infected cultures. They used APP-transfected human neuroblastoma cells (SK-N-MC)