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177423 RESULTS

APP23 x PS1-R278I

RESEARCH MODELS This mouse model is a cross between a well-characterized APP transgenic (APP23) and a PSEN1 knock-in mouse (PS1-R278I) that expresses human PSEN1 with a mutation linked to atypical AD. The R278I mutation alters γ-secretase processing of APP leading to ...

MAPT K317N

MUTATIONS MAPT Exon 11 Point, Missense Coding Impaired tubulin polymerization. Altered tau aggregation in an isoform-specific manner; accelerated tau assembly in 4R tau while decreasing tau aggregation, misfolding, and filament assembly in 3R tau. Lobar atrophy, ...

NeuroNEXT Infrastructure Resource Access (X01)

GRANT Monday, May 4, 2015- 12:30 National Institute of Neurological Disorders and Stroke The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Applications are accepted by continuous ...

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