COMMENT The study of NfL in autosomal-dominant AD (ADAD) provides exciting preliminary evidence supporting this as a progression marker. The effect size was much more impressive in symptomatic patients than in preclinical carriers, and it will be interesting to ...
RESEARCH NEWS 2017-11-17 Research News It works! Neurofilament light chain (NfL) has emerged as the most promising fluid marker for tracking the progression of neurodegenerative disease. Unlike many other biomarkers, blood levels correlate closely with those in cerebrospinal ...
COMMENT We would like to thank all for their comments. With regard to Joseph Castellano’s comment in particular: It is reasonable that certain substances in the blood of AD mice, such as inflammatory cytokines, may enter the blood of parabiotic wild-type mice, ...
PAPER Novakova L, Zetterberg H, Sundström P, Axelsson M, Khademi M, Gunnarsson M, Malmeström C, Svenningsson A, Olsson T, Piehl F, Blennow K, Lycke J29079686
PAPER Mielke MM, Otto M29070663
University of Mississippi Medical CenterJackson, United States
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