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Mouse with Endogenous SOD1 Mutation: A New Model of Early ALS?

RESEARCH NEWS 2014-12-17 Research News For the first time, researchers investigating the role of superoxide dismutase 1 in amyotrophic lateral sclerosis have a rodent model that does not grossly overexpress the gene. Scientists have characterized mice with an ALS-linked mutation ...

PAPER Quwailid MM, Hugill A, Dear N, Vizor L, Wells S, Horner E, Fuller S, Weedon J, McMath H, Woodman P, Edwards D, Campbell D, Rodger S, Carey J, Roberts A, Glenister P, Lalanne Z, Parkinson N, Coghill EL, McKeone R, Cox S, Willan J, Greenfield A, Keays D, Brady S, Spurr N, Gray I, Hunter J, Brown SD, Cox RD

A gene-driven ENU-based approach to generating an allelic series in any gene.

Mamm Genome. 2004 Aug;15(8):585-91. PubMed: 15457338

Scientists Seek, Find, and Exploit AD Risk Genes

CONFERENCE COVERAGE 2014-12-17 Conference Coverage The genes involved in Alzheimer’s disease harbor both pathogenic and protective factors, and at the annual meeting of the Society for Neuroscience, November 15 to 19 in Washington, D.C., researchers proposed two new variants that might ...

Susan Kirk


World Molecular Imaging Society
United States

Immunotherapy II: Active Approaches Down, New Passive Crops Up

CONFERENCE COVERAGE 2014-12-17 Conference Coverage While researchers pursuing passive immunotherapy approaches struggle to refine trial protocols (see Part 4 of this series), active immunotherapies presented setbacks at the 7th Clinical Trials on Alzheimer’s Disease (CTAD) conference, ...

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