PAPER Wang L, Nuytemans K, Bademci G, Jauregui C, Martin ER, Scott WK, Vance JM, Zuchner S

High-Resolution Survey in Familial Parkinson Disease Genes Reveals Multiple Independent Copy Number Variation Events in PARK2.

Hum Mutat. 2013 Aug;34(8):1071-4. PubMed: 23616242

PAPER Borowsky B, Warner J, Leavitt BR, Tabrizi SJ, Roos RA, Durr A, Becker C, Sampaio C, Tobin AJ, Schulman H

8OHdG is not a biomarker for Huntington disease state or progression.

Neurology. 2013 May 21;80(21):1934-41. PubMed: 23616162

PAPER Paraíso AF, Mendes KL, Santos SH

Brain Activation of SIRT1: Role in Neuropathology.

Mol Neurobiol. 2013 Apr 25; PubMed: 23615921

PAPER Hiltunen M, Haapasalo A, Soininen H

[New risk genes for Alzheimer's disease--biomarkers predicting the disease?].

Duodecim. 2013;129(6):583-8. PubMed: 23614223

PAPER Polk AL

Before Alzheimer's….

J Gerontol Nurs. 2013 Jul;39(7):55-6. PubMed: 23614383

PAPER Sörgjerd KM, Zako T, Sakono M, Stirling PC, Leroux MR, Saito T, Nilsson P, Sekimoto M, Saido TC, Maeda M

Human Prefoldin Inhibits Amyloid-β (Aβ) Fibrillation and Contributes to Formation of Nontoxic Aβ Aggregates.

Biochemistry. 2013 May 8; PubMed: 23614719

PAPER Costanzo M, Zurzolo C

The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration.

Biochem J. 2013 May 15;452(1):1-17. PubMed: 23614720

PAPER De Caluwé J, Dupont G

The progression towards Alzheimer's disease described as a bistable switch arising from the positive loop between amyloids and Ca(2+).

J Theor Biol. 2013 Aug 21;331:12-8. PubMed: 23614875

PAPER Lim D, Iyer A, Ronco V, Grolla AA, Canonico PL, Aronica E, Genazzani AA

Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB.

Glia. 2013 Jul;61(7):1134-45. PubMed: 23616440

PAPER Liu Q, Xie X, Lukas RJ, St John PA, Wu J

A novel nicotinic mechanism underlies β-amyloid-induced neuronal hyperexcitation.

J Neurosci. 2013 Apr 24;33(17):7253-63. PubMed: 23616534

PAPER Johnson AA, Sarthi J, Pirooznia SK, Reube W, Elefant F

Increasing Tip60 HAT levels rescues axonal transport defects and associated behavioral phenotypes in a Drosophila Alzheimer's disease model.

J Neurosci. 2013 Apr 24;33(17):7535-47. PubMed: 23616558

PAPER Crump CJ, Johnson DS, Li YM

Development and Mechanism of γ-Secretase Modulators for Alzheimer's Disease.

Biochemistry. 2013 May 2; PubMed: 23614767

PAPER Dorsey ER, George BP, Leff B, Willis AW

The coming crisis: obtaining care for the growing burden of neurodegenerative conditions.

Neurology. 2013 May 21;80(21):1989-96. PubMed: 23616157

PAPER Pause BM, Zlomuzica A, Kinugawa K, Mariani J, Pietrowsky R, Dere E

Perspectives on episodic-like and episodic memory.

Front Behav Neurosci. 2013;7:33. PubMed: 23616754

Mikko Hiltunen on Does Progranulin Play Both Sides in AD and FTD?

COMMENT Perry et al. have identified two patients with Alzheimer’s disease (AD) pathology who also have a mutation in the progranulin (GRN) gene. This is an extremely important finding, considering that the GRN mutations are known to cause the autosomal-dominant