330988 RESULTS
COMMENT The significance of these findings, which now validate the phenomenon of SNAP, cannot be overstated. In 2009, based on the data then available, I suggested that amyloid is not the cause of AD, but a cause of AD (Pimplikar, 2009), and that amyloid-independ
RESEARCH MODELS Summary Like the J20 mice, these mice over-express human APP with the Swedish and Indiana mutations. Transgene expression level is relatively low in J9 mice, approximately half the expression seen in J20 mice. Compared with J20 mice, J9 mice develop amylo
RESEARCH MODELS Modification Details A human APP minigene with the Swedish, Indiana, and Arctic mutations driven by the platelet-derived growth factor β-chain promoter. Neuropathology Parenchymal neuritic plaques by two months accompanied by dystrophic neurites. Prominen
COMMENT This is a good paper. 0 sara_shaheen665
CONFERENCE COVERAGE 2013-11-20 Conference Coverage Several proteins linked to amyotrophic lateral sclerosis and frontotemporal dementia show up in stress granules. These natural RNA-protein accumulations protect essential RNAs in times of cellular strife, but cause trouble if they fail
RESEARCH NEWS 2013-11-20 Research News In a paper in press in Brain Research, researchers have given one mouse model of TDP-43 proteinopathy a thumbs-down. While it was the first such mouse to be published (see Oct 2009 news story), it fails to mimic key features of amyotrophic l
PAPER Kerstein AH, Schroeder RW, Baade LE, Lincoln J, Khan AY
PAPER Kahn DA
PAPER Riemensperger T, Issa AR, Pech U, Coulom H, Nguyễn MV, Cassar M, Jacquet M, Fiala A, Birman S
PAPER Hilton D, Stephens M, Kirk L, Edwards P, Potter R, Zajicek J, Broughton E, Hagan H, Carroll C
PAPER Grant RA, Sharp PS, Kennerley AJ, Berwick J, Grierson A, Ramesh T, Prescott TJ
PAPER Fernagut PO, Meissner WG, Biran M, Fantin M, Bassil F, Franconi JM, Tison F
PAPER Jeantet Y, Cayzac S, Cho YH
PAPER Zanon A, Rakovic A, Blankenburg H, Doncheva NT, Schwienbacher C, Serafin A, Alexa A, Weichenberger CX, Albrecht M, Klein C, Hicks AA, Pramstaller PP, Domingues FS, Pichler I
PAPER Rothman SM, Griffioen KJ, Fishbein KW, Spencer RG, Makrogiannis S, Cong WN, Martin B, Mattson MP
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