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Milton Keynes, United Kingdom
Massachusetts General Hospital/Harvard Medical SchoolCambridge, United States
COMMENT Chronic hippocampal seizures impair cognition, an all-too-common biological comorbidity of temporal lobe epilepsy. What can be done? In the face of irreversible hippocampal cell loss followed by extensive structural rearrangements due to axonal sprouting, ...
RESEARCH NEWS 2017-10-20 Research News In Alzheimer’s disease, seizures in the hippocampus contribute to cognitive decline. Scientists have known for some time that this correlates with persistent loss of the calcium-binding protein calbindin-D28k, a regulator of synaptic ...
PAPER Karádi K, Janszky J, Gyimesi C, Horváth Z, Lucza T, Dóczi T, Kállai J, Abrahám H
Correlation between calbindin expression in granule cells of the resected hippocampal dentate gyrus and verbal memory in temporal lobe epilepsy.Epilepsy Behav. 2012 Sep;25(1):110-9. Epub 2012 Jul 15 PubMed: 22796338
PAPER Nahm WK, Noebels JL
Nonobligate role of early or sustained expression of immediate-early gene proteins c-fos, c-jun, and Zif/268 in hippocampal mossy fiber sprouting.J Neurosci. 1998 Nov 15;18(22):9245-55. PubMed: 9801364
RESEARCH NEWS 2017-10-20 Research News ALS used to be thought of as a disease purely of the motor system, but more recently scientists have uncovered ties with frontotemporal dementia, and even certain neuropsychiatric diseases. Now, scientists led by Orla Hardiman, Beaumont ...
PAPER Lopez-Meraz ML, Wasterlain CG, Rocha LL, Allen S, Niquet J
Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage.Neurobiol Dis. 2010 Feb;37(2):394-402. Epub 2009 Oct 29 PubMed: 19879360
PAPER Nägerl UV, Mody I, Jeub M, Lie AA, Elger CE, Beck H
Surviving granule cells of the sclerotic human hippocampus have reduced Ca(2+) influx because of a loss of calbindin-D(28k) in temporal lobe epilepsy.J Neurosci. 2000 Mar 1;20(5):1831-6. PubMed: 10684884
PAPER Chuquilin M, Wymer S, Wymer J
Increasing Evidence for an Association Between Amyotrophic Lateral Sclerosis and Psychiatric Disorders.JAMA Neurol. 2017 Oct 16; PubMed: 29049449
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