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Taisuke Tomita on New Role For PICALM: Flushing Aβ From the Brain

COMMENT CALM/PICALM is one of the most abundant clathrin adaptors in endocytic clathrin-coated vesicles and regulates the endocytic process at presynaptic active zones of neurons (Blondeau et al., 2004; Koo et al., 2011). Regarding the pathological aspect of ...

New Role For PICALM: Flushing Aβ From the Brain

RESEARCH NEWS 2015-05-29 Research News Genome-wide association studies have fingered PICALM as a consistent link to Alzheimer’s disease. The protein promotes clathrin-mediated endocytosis and has been tied to APP processing and increased Aβ production in neurons. In the May 25 ...

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