PAPER Doecke JD, Laws SM, Faux NG, Wilson W, Burnham SC, Lam CP, Mondal A, Bedo J, Bush AI, Brown B, De Ruyck K, Ellis KA, Fowler C, Gupta VB, Head R, Macaulay SL, Pertile K, Rowe CC, Rembach A, Rodrigues M, Rumble R, Szoeke C, Taddei K, Taddei T, Trounson B, Ames D, Masters CL, Martins RN,
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PAPER Wagner SL, Tanzi RE, Mobley WC, Galasko D
Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease.
Arch Neurol. 2012 Jul 16;:1-4. PubMed: 22801784PAPER Wood H
Alzheimer disease: Prostaglandin E(2) signalling is implicated in inflammation early in the Alzheimer disease course.
Nat Rev Neurol. 2012 Aug;8(8):411. PubMed: 22801972PAPER Warren JD, Fletcher PD, Golden HL
The paradox of syndromic diversity in Alzheimer disease.
Nat Rev Neurol. 2012 Aug;8(8):451-64. PubMed: 22801974PAPER Santa-Maria I, Haggiagi A, Liu X, Wasserscheid J, Nelson PT, Dewar K, Clark LN, Crary JF
The MAPT H1 haplotype is associated with tangle-predominant dementia.
Acta Neuropathol. 2012 Jul 17; PubMed: 22802095PAPER Opara JA
Activities of daily living and quality of life in Alzheimer disease.
J Med Life. 2012 Jun 12;5(2):162-7. PubMed: 22802883Vítor Pinto
ICVS/3B’s - PT Government Associate LaboratoryBraga, Portugal
Pradeep Reddy Raamana
University of PittsburghUnited States
Jens Pahnke on Protective APP Mutation Found—Supports Amyloid Hypothesis
COMMENT This is a nice finding by Jonsson et al., and adds more evidence to the idea published in 2009 by an Italian group that changes to this amino acid position in APP can prevent or facilitate aggregation of human Aβ. It seems that amino acids at position 2 o
Parvathi Rudrabhatla
Research fellowBethesda, United States
Lei Feng on A Boost for Waning DNA Tags Fixes Age-Related Memory Loss in Mice
COMMENT This is very interesting. I am wondering how to relate those findings to the roles of folate in brain function and cognitive aging in humans. Folate provides one carbon group to methylate DNA and other substrates. In population-based studies, low folate h
PAPER Feng L
Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline.
Am J Clin Nutr. 2012 May;95(5):1289-90; author reply 1290. PubMed: 22523150PAPER Feng L, Ng TP, Chuah L, Niti M, Kua EH
Homocysteine, folate, and vitamin B-12 and cognitive performance in older Chinese adults: findings from the Singapore Longitudinal Ageing Study.
Am J Clin Nutr. 2006 Dec;84(6):1506-12. PubMed: 17158436Roberta Diaz Brinton on Alzheimer’s disease: the new promise.
COMMENT This comment by Stephen Strittmatter is based on two critical publications which I highly recommend reading (Talbot et al., 2012; Bomfim et al., 2012). 0 rbrinton Demonstrated brain insulin resistance in Alzheimer's disease patients is associated wit
Matthew Zabel on Protective APP Mutation Found—Supports Amyloid Hypothesis
COMMENT New APP Mutation Does Not Advance the Amyloid Hypothesis Debate In response to the question, Does β amyloid accumulation drive Alzheimer’s disease?, the answer is “most likely no,” and the new data presented by Jonsson et al. does not change that answer.
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