PAPER Jung MS, Park JH, Ryu YS, Choi SH, Yoon SH, Kwen MY, Oh JY, Song WJ, Chung SH

Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation.

J Biol Chem. 2011 Nov 18;286(46):40401-12. PubMed: 21965663

PAPER Jawhar S, Wirths O, Bayer TA

Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer disease.

J Biol Chem. 2011 Nov 11;286(45):38825-32. PubMed: 21965666

PAPER Zhu HL, Meng SR, Fan JB, Chen J, Liang Y

Fibrillization of human tau is accelerated by exposure to lead via interaction with His-330 and His-362.

PLoS One. 2011;6(9):e25020. PubMed: 21966400

C.Y. Daniel Lee

United States

Christina Lineback

University of Michigan, Ann Arbor
United States

Nancy Peng

China

Fabrizio Trinchese

BMS
Rome, Italy

Jerry Soto

Modeling Health
Marina Del Rey, United States

Jürgen Götz on In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice.

COMMENT Dave Holtzman and colleagues have been using the very elegant method of microdialysis, which allowed them to collect ISF (interstitial fluid) from both wild-type and P301L tau transgenic mice, and to infuse tau aggregates. The paper by Yamada et al. furth

Jacqueline Carrillo

Richmond, United States

Virgil Muresan on APP is phosphorylated by TrkA and regulates NGF/TrkA signaling.

COMMENT This study by Matrone et al. establishes a reciprocal, functional link between the post-translational modification of the amyloid-β precursor protein (APP) and the NGF/TrkA signaling pathway that could be relevant to Alzheimer’s disease (AD). This article

Takaomi Saido on Pseudohyperphosphorylation has differential effects on polymerization and function of tau isoforms.

COMMENT An interesting piece of work. 0 saido

Kostas Vekrellis on In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice.

COMMENT This is an elegant study by the Holtzman group which clearly shows that yet another neurodegenerative disease-associated protein, thought to be cytosolic, is found extracellularly in the brain parenchyma. Using an optimized in-vivo microdialysis approach

Montse Soler-Lopez

IRB Barcelona
Barcelona, Spain

ALS: Sticky Tryptophan Achilles' Heel for Superoxide Dismutase?

RESEARCH NEWS 2011-10-03 Research News Much as the enzyme superoxide dismutase 1 protects cells from dangerous free radicals, in amyotrophic lateral sclerosis it may succumb to peer pressure, where malformed enzymes convert others to aggregation-prone forms in a twisted game of m