Jeffery Larkin

United States

Henry Kao

Lundbeck Research USA
Paramus, United States

Amit Bodhani

United States

James Galvin on The AD8—Dementia Screen Ready for Prime Time?

COMMENT Reply to comment by Emory Hill The AD8 was designed as an informant assessment to screen for the presence of cognitive impairment of any cause. However, during its development, we also assessed whether in the absence of an informant, the AD8 would be suff

Gilbert J. Ho on A β-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain.

COMMENT No doubt, dementia with Lewy bodies (DLB) is a complex disease with many possible factors contributing to the pathogenesis. Hashimoto and colleagues show that the P123H mutation in β-synuclein linked to DLB causes neurodegeneration in a mouse model, and t

James Galvin

New York University Langone Medical Center
New York, United States

CI-MPR

ANTIBODY polyclonal manufacturer Cat# ab61774 immunogen = synthetic non-phosphopeptide derived from human Mannose 6 Phosphate Receptor (Cation independent) around the phosphorylation site of serine 2484 (D-D-S-D-E) liquid, affinity purified, PBS, saline, glycerol,

Emory Hill on The AD8—Dementia Screen Ready for Prime Time?

COMMENT You cite Galvin et al., 2007, as evidence that "when a qualified informant is not at hand" (or, for that matter not conscientious, unbiased relatives most likely to accompany research subjects to their research appointments), the participant can

CI-MPR

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CI-MPR

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David Corbin on Brain T Cells Lie in Wait for Recurrent Infections

COMMENT Joseph Prandota at the University Medical School in Wroclaw, Poland, suggests that Toxoplasma gondii (T. gondii), the parasitic protozoa hosted in cats, which causes cerebral toxoplasmosis (CT), may be implicated in the pathogenesis of Alzheimer's di

Mike Massen on Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis.

COMMENT This is extremely interesting and suggests that adoption of an early prophylactic treatment for reduction of Aβ in the blood/tissues by singular or composite (safe) mechanisms over the long term may reduce the likelihood of brain amyloidosis in the aging

Chris Carter on APP, APOE, complement receptor 1, clusterin and PICALM and their involvement in the herpes simplex life cycle.

COMMENT These are not the only Alzheimer's disease-related genes that are implicated in the viral life cycle. Others are catalogued at Polygenic Signaling Pathways, and there is also a database of Herpes simplex host viral interactions. It is worth pointing

EEA1 (C45B10)

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EEA1

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