Combination Trials: FDA Puts Flesh on Bones of Draft Guidance

CONFERENCE COVERAGE 2013-02-15 Conference Coverage When the U.S. Food and Drug Administration in 2010 issued a draft guidance on developing drug combinations, it was written primarily with anti-infectives and cancer drugs in mind. Alzheimer's disease clinicians who have read the g

Brain Electrodes Help Early PD, But Still Risky and Costly

RESEARCH NEWS 2013-02-15 Research News Electrodes inserted into specific brain areas can help some people with advanced Parkinson’s disease (PD) who no longer respond well to medication. Now, research in the February 14 New England Journal of Medicine suggests that the therapy, k

PAPER Kiely AP, Asi YT, Kara E, Limousin P, Ling H, Lewis P, Proukakis C, Quinn N, Lees AJ, Hardy J, Revesz T, Houlden H, Holton JL

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?

Acta Neuropathol. 2013 May;125(5):753-69. PubMed: 23404372

PAPER Jahanshahi A, Vlamings R, Roon-Mom WV, Faull RL, Waldvogel HJ, Janssen ML, Yakkioui Y, Zeef D, Kocabicak E, Steinbusch HW, Temel Y

Changes in brainstem serotonergic and dopaminergic cell populations in experimental and clinical Huntington's disease.

Neuroscience. 2013 Feb 8; PubMed: 23403175

PAPER Gianforcaro A, Solomon JA, Hamadeh MJ

Vitamin D(3) at 50x AI attenuates the decline in paw grip endurance, but not disease outcomes, in the G93A mouse model of ALS, and is toxic in females.

PLoS One. 2013;8(2):e30243. PubMed: 23405058

PAPER Linares E, Seixas LV, Dos Prazeres JN, Ladd FV, Ladd AA, Coppi AA, Augusto O

Tempol moderately extends survival in a hSOD1(G93A) ALS rat model by inhibiting neuronal cell loss, oxidative damage and levels of non-native hSOD1(G93A) forms.

PLoS One. 2013;8(2):e55868. PubMed: 23405225

PAPER Bagchi DP, Yu L, Perlmutter JS, Xu J, Mach RH, Tu Z, Kotzbauer PT

Binding of the radioligand SIL23 to α-synuclein fibrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent.

PLoS One. 2013;8(2):e55031. PubMed: 23405108

PAPER Leung AY, Kwan CW, Chi I

Residents with Alzheimer's disease in long-term care facilities in Hong Kong: patterns of hospitalization and emergency room use.

Aging Ment Health. 2013 Feb 12; PubMed: 23402396

PAPER Peng CX, Hu J, Liu D, Hong XP, Wu YY, Zhu LQ, Wang JZ

Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model.

Neurobiol Aging. 2013 Jun;34(6):1555-63. Epub 2013 Feb 10 PubMed: 23402899

PAPER Rojas S, Herance JR, Gispert JD, Abad S, Torrent E, Jiménez X, Pareto D, Perpiña U, Sarroca S, Rodríguez E, Ortega-Aznar A, Sanfeliu C

In vivo evaluation of amyloid deposition and brain glucose metabolism of 5XFAD mice using positron emission tomography.

Neurobiol Aging. 2013 Jul;34(7):1790-8. PubMed: 23402900

PAPER Stevens CB, Hanna JM, Lammi RK

Synthesis of tetrahydroxybiphenyls and tetrahydroxyterphenyls and their evaluation as amyloid-β aggregation inhibitors.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1703-6. PubMed: 23403086

PAPER Kim SE, Ko IG, Shin MS, Kim CJ, Jin BK, Hong HP, Jee YS

Treadmill exercise and wheel exercise enhance expressions of neutrophic factors in the hippocampus of lipopolysaccharide-injected rats.

Neurosci Lett. 2013 Mar 22;538:54-9. PubMed: 23403101

PAPER Min D, Guo F, Zhu S, Xu X, Mao X, Cao Y, Lv X, Gao Q, Wang L, Chen T, Shaw C, Hao L, Cai J

The alterations of Ca2+/calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer's disease and vascular dementia.

Neurosci Lett. 2013 Mar 22;538:60-5. PubMed: 23403102

PAPER Nishida K, Morishima Y, Yoshimura M, Isotani T, Irisawa S, Jann K, Dierks T, Strik W, Kinoshita T, Koenig T

EEG microstates associated with salience and frontoparietal networks in frontotemporal dementia, schizophrenia and Alzheimer's disease.

Clin Neurophysiol. 2013 Feb 9; PubMed: 23403263

PAPER Cotroneo AM, Castagna A, Putignano S, Lacava R, Fantò F, Monteleone F, Rocca F, Malara A, Gareri P

Effectiveness and safety of citicoline in mild vascular cognitive impairment: the IDEALE study.

Clin Interv Aging. 2013;8:131-7. PubMed: 23403474