Suhail Rasool on Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening.

COMMENT This is good work. The biomarker is the most important tool for studying AD. The authors report results for a small number of patients for whom diagnosis was confirmed at autopsy. It is also very important to diagnose in living subjects who have early AD

Mark E. Obrenovich on Mark Smith, 45, Is Struck and Killed by Hit-and-Run Driver

COMMENT I was Mark's graduate student. I want to please request that all of his friends, associates, and admirers contribute to a special hot topic issue, "Polyphenolic Antioxidants in Health Disease and Aging," in Immunology, Endocrine & Metab

Ben Gittings

Woodland Park, United States

PAPER McKinney RA

Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling.

J Physiol. 2010 Jan 1;588(Pt 1):107-16. PubMed: 19933758

PAPER Richards DA, Mateos JM, Hugel S, De Paola V, Caroni P, Gähwiler BH, McKinney RA

Glutamate induces the rapid formation of spine head protrusions in hippocampal slice cultures.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6166-71. PubMed: 15831587

PAPER McKinney RA, Capogna M, Dürr R, Gähwiler BH, Thompson SM

Miniature synaptic events maintain dendritic spines via AMPA receptor activation.

Nat Neurosci. 1999 Jan;2(1):44-9. PubMed: 10195179

Grace Stutzmann on The concentration of soluble extracellular amyloid-β protein in acute brain slices from CRND8 mice.

COMMENT Given the increasing trend of studying the biological effects of β amyloid in live tissue preparations rather than biochemically, this study is particularly relevant and eye opening. The rigorous and biophysical nature of this study shouldn't intimid

VPS35 (C-20)

ANTIBODY polyclonal manufacturer sc-55803 <br />Reference:<br /><a href="/papers/retrieval-alzheimers-amyloid-precursor-protein-endosome-tgn-s655-phosphorylation-state" target="_new">Vieira SI, 2010</a> immunogen = a pep

Tau’s Synaptic Hats: Regulating Activity, Disrupting Communication

RESEARCH NEWS 2011-01-18 Research News What does the axonal protein tau have to do with synapses? Quite a bit, some scientists say. As researchers continue to dig for the roots of Alzheimer’s disease, they are turning up more evidence that tau can have powerful effects on synapti

PAPER Drew PJ, Shih AY, Driscoll JD, Knutsen PM, Blinder P, Davalos D, Akassoglou K, Tsai PS, Kleinfeld D

Chronic optical access through a polished and reinforced thinned skull.

Nat Methods. 2010 Dec;7(12):981-4. PubMed: 20966916

Lisa Stone

South Africa

Cathepsin D (49)

ANTIBODY monoclonal 49 manufacturer Cat# 610800/01 immunogen = aa. 173-359 of human cathepsin B liquid, aqueous buffered solution, purified, BSA, glycerol, azide detects cathepsin D IgG_2a Proteases BD Transduction Mouse Human Cathepsin D htt

Rab5

ANTIBODY polyclonal manufacturer Cat# ADI-KAP-GP00<br />Reference: <br /><a href="/papers/retrieval-alzheimers-amyloid-precursor-protein-endosome-tgn-s655-phosphorylation-state" target="_new">Vieira SI, 2010</a> immunoge

Seeing Is Believing—Plaque Growth Is Slow, Tapers With Age

RESEARCH NEWS 2011-01-17 Research News To understand how amyloid plaques, the troublesome clumps of Aβ, form and grow in the brain, it helps to just watch the action directly. Advances in multiphoton microscopy have made this possible, allowing scientists to see individual plaque

Clathrin, heavy chain

ANTIBODY polyclonal manufacturer ICN Immunobiologicals<br />Cat# 657811<br />Reference: <br /><a href="/papers/retrieval-alzheimers-amyloid-precursor-protein-endosome-tgn-s655-phosphorylation-state" target="_new">Vieira