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Transient expression of doublecortin during adult neurogenesis.

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Adult-born hippocampal neurons are more numerous, faster maturing, and more involved in behavior in rats than in mice.

J Neurosci. 2009 Nov 18;29(46):14484-95. PubMed: 19923282

Gerd Kempermann on Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months.

COMMENT This is indeed an interesting paper. If neuronal maturation in primates takes so much longer than in rodents, this has many implications. The current idea is that there is a time window during this maturation when new cells are particularly sensitive. The

Gerd Kempermann

Center for Regenerative Therapies
Dresden, Germany

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Oppositional effects of serotonin receptors 5-HT1a, 2, and 2c in the regulation of adult hippocampal neurogenesis.

Front Mol Neurosci. 2010;3 PubMed: 20721314

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Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months.

Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10326-31. PubMed: 21646517

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Watching Adult Neurogenesis—In Primates It Takes Time

RESEARCH NEWS 2011-06-11 Research News Two places in the brain support the regular rise of new neurons. In the dentate gyrus of the hippocampus, neurogenesis is thought to support learning and memory (reviewed in Deng et al., 2010), and in the olfactory bulb, it may allow animals

Is Motor Neuron Troublemaker Just a Bad Driver?

RESEARCH NEWS 2011-06-11 Research News The protein survival of motor neuron (SMN), whose absence causes spinal muscular atrophy, has a new charge: an mRNA needed to make neuromuscular junctions. Together with the RNA-binding protein HuD, SMN picks up the mRNA for cpg15 (candidate

PAPER Fujioka S, Wszolek ZK

Clinical aspects of familial forms of frontotemporal dementia associated with parkinsonism.

J Mol Neurosci. 2011 Nov;45(3):359-65. PubMed: 21656039

PAPER Deleersnijder A, Van Rompuy AS, Desender L, Pottel H, Buée L, Debyser Z, Baekelandt V, Gerard M

Comparative analysis of different peptidyl-prolyl isomerases reveals FK506-binding protein 12 as the most potent enhancer of alpha-synuclein aggregation.

J Biol Chem. 2011 Jul 29;286(30):26687-701. PubMed: 21652707

PAPER Gwinn K, Devine MJ, Jin LW, Johnson J, Bird T, Muenter M, Waters C, Adler CH, Caselli R, Houlden H, Lopez G, Singleton A, Hardy J

Clinical features, with video documentation, of the original familial lewy body parkinsonism caused by α-synuclein triplication (Iowa kindred).

Mov Disord. 2011 Sep;26(11):2134-6. PubMed: 21656851