PAPER Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR Jr, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, Yaffe K, Carrillo MC, Thies B, Morrison-Bogorad M, Wagster MV, Phelps CH
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PAPER Leoni V, Caccia C
Oxysterols as biomarkers in neurodegenerative diseases.
Chem Phys Lipids. 2011 Sep;164(6):515-24. PubMed: 21515244PAPER Pinton S, da Rocha JT, Gai BM, Nogueira CW
Sporadic dementia of Alzheimer's type induced by streptozotocin promotes anxiogenic behavior in mice.
Behav Brain Res. 2011 Sep 30;223(1):1-6. PubMed: 21515307PAPER Ding BJ, Ma WW, He LL, Zhou X, Yuan LH, Yu HL, Feng JF, Xiao R
Soybean isoflavone alleviates β-amyloid 1-42 induced inflammatory response to improve learning and memory ability by down regulation of Toll-like receptor 4 expression and nuclear factor-κB activity in rats.
Int J Dev Neurosci. 2011 Aug;29(5):537-42. PubMed: 21515354PAPER Caruso P, Burla R, Piersanti S, Cherubini G, Remoli C, Martina Y, Saggio I
Prion expression is activated by Adenovirus 5 infection and affects the adenoviral cycle in human cells.
Virology. 2009 Mar 15;385(2):343-50. PubMed: 19138779PAPER Lötscher M, Recher M, Lang KS, Navarini A, Hunziker L, Santimaria R, Glatzel M, Schwarz P, Böni J, Zinkernagel RM
Induced prion protein controls immune-activated retroviruses in the mouse spleen.
PLoS One. 2007;2(11):e1158. PubMed: 17987132PAPER Leblanc P, Baas D, Darlix JL
Analysis of the interactions between HIV-1 and the cellular prion protein in a human cell line.
J Mol Biol. 2004 Apr 2;337(4):1035-51. PubMed: 15033368Chris Carter on Reimagining Alzheimer's Disease—Time for Bright New Ideas?
COMMENT I fully agree with Karl Herrup’s diagnosis that the early detection of risk factors, and their elimination could lead to novel therapeutic and preventive strategies in Alzheimer’s disease. I would also go further and suggest that many of these risk factor
PAPER Jiménez-Jiménez FJ, Molina JA, de Bustos F, Ortí-Pareja M, Benito-León J, Tallón-Barranco A, Gasalla T, Porta J, Arenas J
Serum levels of beta-carotene, alpha-carotene and vitamin A in patients with Alzheimer's disease.
Eur J Neurol. 1999 Jul;6(4):495-7. PubMed: 10362906Peter Nelson on Reimagining Alzheimer's Disease—Time for Bright New Ideas?
COMMENT I have much respect for Dr. Herrup and for his scholarly review article. I agree that dementia comes from many different diseases, and aging no doubt plays a role in some dementia subtypes. Focusing on non-AD processes linked to aging is laudable and impo
Xuekai Zhang on Stress and Trauma: Blast Injuries in the Military
COMMENT Such interesting reports. These researchers may have not only revealed a truly new and unique phenomenon, but also given rise to some new ideas on the etiological research of various dementias. Looking forward to reading the other parts of this report. zh
D. Stephen Snyder on Stress and Trauma: Shaken Brains, Shaken Lives
COMMENT Worth thinking about, too, in this context, are the shaken babies who survive and the impact that such trauma will have on their neural development. ss82f 0
Russell Swerdlow on Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
COMMENT In this paper, the Reddy lab presents additional evidence of an Aβ-mitochondrial nexus. They report that mitochondrial fission-fusion is imbalanced in AD subject brains and in transgenic mice expressing human mutant β APP. The human brain work is particul
David Knopman on Lack of evidence for the efficacy of memantine in mild Alzheimer disease.
COMMENT Schneider et al. present a reanalysis of three studies of memantine in mild to moderate Alzheimer’s disease (AD) in which they were able to isolate the data for the mild subjects. They find no benefits for memantine in milder AD dementia patients. Schneid
PAPER Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW
Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies.
Acta Neuropathol. 2011 May;121(5):571-87. PubMed: 21516511Current Filters
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