CONFERENCE 2005-02-17 00:00:00-2005-02-21 00:00:00 Washington, DC, U.S.A. 17 – 21 February 2005 2005 Annual Meeting Focusing on "The Nexus: Where Science Meets Society" Some 17 tentative session tracks were proposed by the AAAS Program Committee, with topics ranging from emerging disea
CONFERENCE 2005-02-12 00:00:00-2005-02-17 00:00:00 Eldorado Hotel, Santa Fe, NM, U.S.A. 12 – 17 February 2005 With the completion of the human genome project, we will shortly know all of the cytokines encoded within our genome. Indeed within the last few years, there have been reports of at leas
CONFERENCE 2005-02-02 00:00:00-2005-02-02 00:00:00 New York Academy of Sciences, New York, NY, U.S.A. 02 February 2005 The NY Academy of Sciences Neuroimmunology Discussion group invites you to participate in a poster session at its next meeting on February 2, 2005. Topic: Microglia: How They Function in
CONFERENCE 2005-02-01 00:00:00-2005-02-07 00:00:00 Fairmont Hotel Vancouver, Vancouver, British Columbia, Canada 01 – 07 February 2005 The decision to activate an immune response is made by unique antigen presenting cells, called dendritic cells that are resting until they encounter foreign micr
CONFERENCE 2005-01-29 00:00:00-2005-02-04 00:00:00 Banff Centre, Banff, Alberta, Canada 29 January – 04 February 2005 Nuclear Magnetic Resonance (NMR) has a long history of evolving to meet new challenges of molecular biology; this evolution will be even more rapid in a genomic and post-genomic
MUTATIONS PSEN1 73640373 GRCh37/hg19 rs63750391 G C g.25641G> C g.42195G> C Exon 5 Point, Missense Coding Increased Aβ42/Aβ40 and Aβ42/Aβ38; unchanged Aβ38/Aβ40 and Aβ43/Aβ40 in iPSC-derived neurons. Altered protein stability. Also, disrupted lysosome functio
MUTATIONS PSEN1 73640373 GRCh37/hg19 rs63750391 G A g.25641G> A g.42195G> A Exon 5 Point, Missense Coding Increased Aβ42/Aβ40 and Aβ42/Aβ38; unchanged Aβ38/Aβ40 and Aβ43/Aβ40 in iPSC-derived neurons. Altered protein stability. Also, disrupted lysosome functio
MUTATIONS PSEN1 73640371 GRCh37/hg19 rs63750306 A T g.25639A> T g.42193A> T Exon 5 Point, Missense Coding Increased Aβ42, Aβ42/Aβ total, Aβ42/Aβ40 in cells and in vitro assays and decreased Aβ37/Aβ42. Impaired calcium dynamics, mitochondrial permeability, exp
MUTATIONS PSEN1 73640371 GRCh37/hg19 rs63750306 A G g.25639A> G g.42193A> G Exon 5 Point, Missense Coding Increased Aβ42/Aβ40 ratio; increased Aβ42 and Aβ43; lowered wild-type PSEN1 gene expression. Disrupted endosomes via accumulation of APP β-CTF. Disrupted