PAPER Bloor CM
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Brian O’Nuallain on Conformational conversion during amyloid formation at atomic resolution.
COMMENT This elegant study by Eichner et al. considerably advances atomic-level understanding of the molecular features that underlie human β 2-microglobulin (β 2 m) amyloidogenecity, and should facilitate the development of novel therapeutics for dialysis-relate
CD11b/CD18 αMβ2 Integrin (ED7)
ANTIBODY monoclonal ED7 manufacturer Cat# MAB1408 immunogn = spleen cell homogenate with FCA liquid, ascites, protein-A affinity purified, PBS, azide. recognizes a membrane antigen on rat macrophages, monocytes, dendritic cells and granulocytes; recognizes small r
Wai-Tong Chien on Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study.
COMMENT I am very delighted to further understand that exercise can help preserve gray matter and thus may help prevent Alzheimer's disease in older people. This is particularly critical to populations at greatest lifetime risk for development of AD. Everywh
PAPER Radford SE, Gosal WS, Platt GW
Towards an understanding of the structural molecular mechanism of beta(2)-microglobulin amyloid formation in vitro.
Biochim Biophys Acta. 2005 Nov 10;1753(1):51-63. PubMed: 16099226PAPER Liu C, Sawaya MR, Eisenberg D
β₂-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages.
Nat Struct Mol Biol. 2011 Jan;18(1):49-55. PubMed: 21131979PAPER Giorgetti S, Rossi A, Mangione P, Raimondi S, Marini S, Stoppini M, Corazza A, Viglino P, Esposito G, Cetta G, Merlini G, Bellotti V
Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen.
Protein Sci. 2005 Mar;14(3):696-702. PubMed: 15689502PAPER Esposito G, Michelutti R, Verdone G, Viglino P, Hernández H, Robinson CV, Amoresano A, Dal Piaz F, Monti M, Pucci P, Mangione P, Stoppini M, Merlini G, Ferri G, Bellotti V
Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation.
Protein Sci. 2000 May;9(5):831-45. PubMed: 10850793PAPER Bellotti V, Stoppini M, Mangione P, Sunde M, Robinson C, Asti L, Brancaccio D, Ferri G