PAPER Firbank MJ, He J, Blamire AM, Singh B, Danson P, Kalaria RN, O'Brien JT
SEARCH RESULTS
329960 RESULTS
PAPER Vinkers DJ, van der Mast RC
Temporal course of depressive symptoms during the development of Alzheimer disease: blowing hot and cold over depression and cognitive impairment.
Neurology. 2011 Apr 26;76(17):1531; author reply 1531, discussion 1531-2. PubMed: 21519007PAPER Pan C, Xu Z, Dong Y, Zhang Y, Zhang J, McAuliffe S, Yue Y, Li T, Xie Z
The potential dual effects of anesthetic isoflurane on hypoxia-induced caspase-3 activation and increases in β-site amyloid precursor protein-cleaving enzyme levels.
Anesth Analg. 2011 Jul;113(1):145-52. PubMed: 21519046Norman Relkin on Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease.
COMMENT It is gratifying to see a consensus emerging about the existence of naturally occurring conformation-selective anti-amyloid antibodies in human plasma and intravenous immunoglobulin (IVIG). This publication by Dodel and colleagues adds to reports by O’Nua
Paul Szabo
Weill Cornell Medical CollegeUnited States
Xiongwei Zhu on Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
COMMENT It is increasingly accepted that abnormal mitochondrial dynamics likely underlie mitochondrial dysfunction in AD. Despite some discrepancy with the prior publications from our group, this is an interesting paper that adds important in vivo evidence suppor
M. Flint Beal on Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
COMMENT This manuscript provides further data that point to dysfunctional mitochondria in AD. The authors measured a number of proteins that play a critical role in mitochondrial dynamics and turnover. They found that there is increased dynamin-related peptide (D