PAPER Riccio A, Medhurst AD, Mattei C, Kelsell RE, Calver AR, Randall AD, Benham CD, Pangalos MN
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PAPER Wenning AS, Neblung K, Strauss B, Wolfs MJ, Sappok A, Hoth M, Schwarz EC
TRP expression pattern and the functional importance of TRPC3 in primary human T-cells.
Biochim Biophys Acta. 2011 Mar;1813(3):412-23. PubMed: 21215279PAPER Tobe M, Isobe Y, Tomizawa H, Nagasaki T, Takahashi H, Hayashi H
A novel structural class of potent inhibitors of NF-kappa B activation: structure-activity relationships and biological effects of 6-aminoquinazoline derivatives.
Bioorg Med Chem. 2003 Sep 1;11(18):3869-78. PubMed: 12927847PAPER Wu J, Shih HP, Vigont V, Hrdlicka L, Diggins L, Singh C, Mahoney M, Chesworth R, Shapiro G, Zimina O, Chen X, Wu Q, Glushankova L, Ahlijanian M, Koenig G, Mozhayeva GN, Kaznacheyeva E, Bezprozvanny I
Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington's disease treatment.
Chem Biol. 2011 Jun 24;18(6):777-93. PubMed: 21700213PAPER Makhortova NR, Hayhurst M, Cerqueira A, Sinor-Anderson AD, Zhao WN, Heiser PW, Arvanites AC, Davidow LS, Waldon ZO, Steen JA, Lam K, Ngo HD, Rubin LL
A screen for regulators of survival of motor neuron protein levels.
Nat Chem Biol. 2011 Aug;7(8):544-52. PubMed: 21685895Bertrand Kleizen
Utrecht University, Faculty of ScienceUtrecht, Netherlands
Larysa Voytenko
Karolinska InstituteStockholm, Sweden
Uppsala: Conference Puts Uppsala on Immunotherapy Map
CONFERENCE COVERAGE 2011-06-28 Conference Coverage Founded in 1477, Uppsala University in Sweden has a long tradition of advancing the cutting edge of medicine, from its pharmacopeiac gardens tended by Carl Linnaeus of taxonomy fame, to a seventeenth-century anatomy theater hosting pub
Broad Screens Yield Pathologic Pathways for Huntington’s, SMA
RESEARCH NEWS 2011-06-28 Research News The classic scientific method requires a hypothesis—but sometimes it can be refreshing to dive in without one. The authors of two screens, published this week, took just that approach and came up with pathological pathways linked to two diff
Sanjay Pimplikar on Can Diet Influence Alzheimer’s Disease Biomarkers?
COMMENT These are interesting studies, and the conclusions drawn by the authors, though based on a relatively low "n" (nine-15 subjects per group) and a short duration of treatment (four weeks), provide food for thought. Numerous studies have shown (1)
PAPER Bulló M, Casas-Agustench P, Amigó-Correig P, Aranceta J, Salas-Salvadó J
Inflammation, obesity and comorbidities: the role of diet.
Public Health Nutr. 2007 Oct;10(10A):1164-72. PubMed: 17903326S Pablo Sardi on Feedback Loop—Molecular Mechanism for PD, Gaucher’s Connection
COMMENT Unique clinical observations and elegant genetic research have established that approximately 10-12 percent of people with Parkinson’s have a mutation in one copy of a gene encoding the lysosomal enzyme glucocerebrosidase, or GBA1 (Sidransky et al., 2009)
Brian Spencer on Feedback Loop—Molecular Mechanism for PD, Gaucher’s Connection
COMMENT Mazzulli et al. describe an incredibly important study linking the activity of the lysosomal enzyme, glucocerebrosidase, with the accumulation and fibrilization of α-synuclein. Their study extends previous research into the correlation of glucocerebrosida
Brian Spencer
University of California, San DiegoSan Diego, United States
Laura Parkkinen on Feedback Loop—Molecular Mechanism for PD, Gaucher’s Connection
COMMENT This certainly is an impressive amount of work focusing thoroughly on the mechanistic link between glucocerebrosidase (GCase), glucocerebroside (GlcCer), and α-synuclein by robustly combining, in vitro, Gaucher's disease (GD), animal model, and human
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