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331202 RESULTS

BRI-Aβ42 (BRI2-Aβ42)

RESEARCH MODELS Summary These transgenic mice overexpress Aβ42 without overexpressing APP. They contain a fusion construct of the BRI protein, which is involved in amyloid deposition in Familial British Dementia (FBD) and Familial Danish Dementia (FDD), and Aβ42. Twenty-

BRI-Aβ40 (BRI2-Aβ40)

RESEARCH MODELS Modification Details Construct encodes a fusion protein of the BRI protein and Aβ40 driven by the mouse prion promoter; Aβ40 is secreted through proteolytic cleavage of the protein at a furin cleavage site immediately preceding Aβ40. Summary These transge

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