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sAPP Binds GABA Receptor, and More News on APP

CONFERENCE COVERAGE 2017-07-21 Conference Coverage Researchers convened last month in Heidelberg, Germany, could have been forgiven for thinking they had been teleported back to AD research of the 1990s. Classic, good old biochemistry captured the limelight at Mechanisms in ...

Tyler Ulland


Washington University in St. Louis
St. Louis, United States

Li-Huei Tsai on C9ORF72 Throws a Wrench into DNA Repair Machinery

COMMENT This study is consistent with our previous work on the relationship of accumulation of DNA damage and neurodegeneration. In our paper published in 2013 in Nature Neuroscience (Wang et al.), we showed that the familial ALS gene product, FUS, a DNA/RNA ...

C9ORF72 Throws a Wrench into DNA Repair Machinery

RESEARCH NEWS 2017-07-21 Research News Hexanucleotide expansions in the C9ORF72 gene—the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia—mount a multipronged attack on the DNA repair system, according to a July 17 study in Nature ...

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