PAPER Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, Kabbach G, Venderova K, Girardin SE, Bulman DE, Scherzer CR, LaVoie MJ, Gris D, Park DS, Angel JB, Shen J, Philpott DJ, Schlossmacher MG
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M. Flint Beal on Protein Destroying Muscle, Bone, Nerves Parks on Mitochondria
COMMENT The link between these two papers is that VCP mutations have deleterious effects on mitochondria. However, the two groups approach this from different directions. Plun-Favreau et al. studied mitochondrial function in fibroblasts and show that there is unc
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Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta.
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2871-6. PubMed: 11226333PAPER Gangemi S, Basile G, Merendino RA, Minciullo PL, Novick D, Rubinstein M, Dinarello CA, Lo Balbo C, Franceschi C, Basili S, D' Urbano E, Daví G, Nicita-Mauro V, Romano M
Increased circulating Interleukin-18 levels in centenarians with no signs of vascular disease: another paradox of longevity?
Exp Gerontol. 2003 Jun;38(6):669-72. PubMed: 12814802Gunnar Gouras on Like Star Born of Supernova, Plaque Born of Exploded Neuron?
COMMENT I'd like to clarify and extend my quoted comments about the interesting talk by Charlie Glabe at the AD/PD meeting. I was mainly referring to his new images of nuclear aggregates. Charlie did also show very nice new images of plaques appearing to ari
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Effect of ampicillin and chloramphenicol against Streptococcus pneumoniae and Neisseria meningitidis.
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Epidural opiates in labour.
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Headache. 1977 Mar 1;17(1):25-7. PubMed: 845024LRRK Watchers’ Eyes Turn to Inflammation, Autophagy, Kinase
CONFERENCE COVERAGE 2013-03-22 Conference Coverage Read a PDF of the entire series. With variants that boost risk for both familial and sporadic Parkinson’s disease, the LRRK2 gene beckons as a prime target for therapy development. But there’s a hitch: No one knows yet how leucine-rich
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