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Do Extended Species of Aβ Poison Synapses, Masquerade As Dimers?

RESEARCH NEWS 2015-05-02 Research News Most studies of Aβ barely look beyond Aβ40 and Aβ42, but researchers have long known that a veritable zoo of APP fragments exist in the human brain. How important are these other species in disease? And how do they change with BACE ...

Vaccine Rouses Mouse Immune System to Fight Motor Neuron Disease

RESEARCH NEWS 2015-05-01 Research News In amyotrophic lateral sclerosis, motor neurons in the spinal cord need some TLC, but the immune cells that could give it are locked out of the central nervous system. According to a study in the April 22 Journal of Neuroscience by Michal ...

Gamma Secretase: Intramembrane Liaisons Revealed

RESEARCH NEWS 2015-05-01 Research News Open the curtains to a clearer picture of who plays footsy with whom in the γ-secretase complex. On April 27 in the Proceedings of the National Academy of Sciences, researchers led by Yigong Shi at Tsinghua University in Beijing described ...

Computational Modeling—Will it Rescue AD Clinical Trials?

WEBINAR 2015-05-01 The Alzheimer's field has had its share of clinical trial flops. Now there's a push to learn from past failures. Computational scientists in pharmaceutical companies are guiding clinical trial design by first putting drug candidates through ...

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