Keystone: Probing the Function of Lipoprotein and Related Receptors

CONFERENCE COVERAGE 2012-03-28 Conference Coverage On the face of it, lipoprotein receptors may not sound like they have much to do with Alzheimer’s disease, or even the central nervous system. But as scientists are finding out more about these multifaceted cell-surface proteins, they

PAPER Mok KY, Koutsis G, Schottlaender LV, Polke J, Panas M, Houlden H

High frequency of the expanded C9ORF72 hexanucleotide repeat in familial and sporadic Greek ALS patients.

Neurobiol Aging. 2012 Aug;33(8):1851.e1-5. PubMed: 22445326

PAPER Mattson MP

Parkinson's disease: don't mess with calcium.

J Clin Invest. 2012 Apr 2;122(4):1195-8. PubMed: 22446181

PAPER Polymenidou M, Lagier-Tourenne C, Hutt KR, Bennett CF, Cleveland DW, Yeo GW

Misregulated RNA processing in amyotrophic lateral sclerosis.

Brain Res. 2012 Jun 26;1462:3-15. PubMed: 22444279

PAPER Xu MF, Xiong YY, Liu JK, Qian JJ, Zhu L, Gao J

Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells.

Acta Pharmacol Sin. 2012 May;33(5):578-87. PubMed: 22447225

PAPER Zuleta A, Vidal RL, Armentano D, Parsons G, Hetz C

AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease.

Biochem Biophys Res Commun. 2012 Apr 13;420(3):558-63. PubMed: 22445760

PAPER Annese V, Barcia C, Ros-Bernal F, Gómez A, Ros CM, de Pablos V, Fernández-Villalba E, De Stefano ME, Herrero MT

Evidence of oligodendrogliosis in MPTP-induced Parkinsonism.

Neuropathol Appl Neurobiol. 2012 Mar 23; PubMed: 22443457

PAPER Xia R, Liu Y, Yang L, Gal J, Zhu H, Jia J

Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS.

Mol Neurodegener. 2012;7:10. PubMed: 22443542

PAPER Fernández-Gamba A, Leal MC, Maarouf CL, Richter-Landsberg C, Wu T, Morelli L, Roher AE, Castaño EM

Collapsin response mediator protein-2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non-lethal oxidative stress.

J Neurochem. 2012 Jun;121(6):985-95. PubMed: 22443207

PAPER Chen BY, Wang X, Chen LW, Luo ZJ

Molecular targeting regulation of proliferation and differentiation of the bone marrow-derived mesenchymal stem cells or mesenchymal stromal cells.

Curr Drug Targets. 2012 Apr;13(4):561-71. PubMed: 22443584

PAPER Corrigan F, Vink R, Blumbergs PC, Masters CL, Cappai R, van den Heuvel C

Evaluation of the effects of treatment with sAPPα on functional and histological outcome following controlled cortical impact injury in mice.

Neurosci Lett. 2012 Apr 25;515(1):50-4. PubMed: 22445885

PAPER Hunter K, Hölscher C

Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis.

BMC Neurosci. 2012;13:33. PubMed: 22443187

PAPER Hsieh CJ, Chu H, Cheng JJ, Shen WW, Lin CC

Validation of apathy evaluation scale and assessment of severity of apathy in Alzheimer's disease.

Psychiatry Clin Neurosci. 2012 Apr;66(3):227-34. PubMed: 22443245

PAPER Bemporad F, Chiti F

Protein misfolded oligomers: experimental approaches, mechanism of formation, and structure-toxicity relationships.

Chem Biol. 2012 Mar 23;19(3):315-27. PubMed: 22444587

PAPER Patel S, Lee EB, Xie SX, Law A, Jackson EM, Arnold SE, Clark CM, Shaw LM, Grady MS, Trojanowski JQ, Hamilton RH

Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus.

Fluids Barriers CNS. 2012;9(1):7. PubMed: 22444461