Jürgen Götz on Extracting β-amyloid from Alzheimer's disease.

COMMENT Nice review of the original article by Sehgal et al. published in PNAS. Randy Bateman's study in Science on the impaired clearance of Aβ in AD supports the approach. 0 j.goetz Withania somnifera reverses Alzheimer's disease pathology by enhancin

Jürgen Götz on Atomic identification of fluorescent Q-dots on tau-positive fibrils in 3D-reconstructed pick bodies.

COMMENT Excellent approach by Uematsu and colleagues to visualize proteinaceous inclusions at the light- and electron microscopic level in parallel. 0 j.goetz

Ravi Anand on Trans-synaptic spread of tau pathology in vivo.

COMMENT The paper makes a major contribution to understanding how AD spreads in the brain, and will help advance the development of an effective therapy for AD. 0 ravi

Takaomi Saido on Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease.

COMMENT Very interesting if reproducible. 0 saido

Karl Richter

Biogen
Cambridge, United States

Yao Hsiang Shih

Taiwan, Province of China

Daniel Hartmann

Germany

Wenzhen Duan on Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.

COMMENT This is an interesting paper, as it is the first to show that in-vivo administration of ganglioside increases mutant huntingtin (mHtt) phosphorylation and improves motor phenotype. Significantly, ganglioside is a natural cell membrane component with rare

Joseph Mazzulli on Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.

COMMENT The paper by Di Pardo et al. shows a remarkable improvement of motor impairment by intraventricular ganglioside GM1 treatment. It is particularly exciting, since this treatment seems to improve the phenotype even after neurological symptoms have presented

Wenzhen Duan

Johns Hopkins University
Baltimore, United States

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Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.

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GM1 ganglioside in Parkinson's disease: Results of a five year open study.

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