PAPER Leblanc P, Baas D, Darlix JL
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Chris Carter on Reimagining Alzheimer's Disease—Time for Bright New Ideas?
COMMENT I fully agree with Karl Herrup’s diagnosis that the early detection of risk factors, and their elimination could lead to novel therapeutic and preventive strategies in Alzheimer’s disease. I would also go further and suggest that many of these risk factor
PAPER Jiménez-Jiménez FJ, Molina JA, de Bustos F, Ortí-Pareja M, Benito-León J, Tallón-Barranco A, Gasalla T, Porta J, Arenas J
Serum levels of beta-carotene, alpha-carotene and vitamin A in patients with Alzheimer's disease.
Eur J Neurol. 1999 Jul;6(4):495-7. PubMed: 10362906Peter Nelson on Reimagining Alzheimer's Disease—Time for Bright New Ideas?
COMMENT I have much respect for Dr. Herrup and for his scholarly review article. I agree that dementia comes from many different diseases, and aging no doubt plays a role in some dementia subtypes. Focusing on non-AD processes linked to aging is laudable and impo
Xuekai Zhang on Stress and Trauma: Blast Injuries in the Military
COMMENT Such interesting reports. These researchers may have not only revealed a truly new and unique phenomenon, but also given rise to some new ideas on the etiological research of various dementias. Looking forward to reading the other parts of this report. zh
D. Stephen Snyder on Stress and Trauma: Shaken Brains, Shaken Lives
COMMENT Worth thinking about, too, in this context, are the shaken babies who survive and the impact that such trauma will have on their neural development. ss82f 0
Russell Swerdlow on Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
COMMENT In this paper, the Reddy lab presents additional evidence of an Aβ-mitochondrial nexus. They report that mitochondrial fission-fusion is imbalanced in AD subject brains and in transgenic mice expressing human mutant β APP. The human brain work is particul
David Knopman on Lack of evidence for the efficacy of memantine in mild Alzheimer disease.
COMMENT Schneider et al. present a reanalysis of three studies of memantine in mild to moderate Alzheimer’s disease (AD) in which they were able to isolate the data for the mild subjects. They find no benefits for memantine in milder AD dementia patients. Schneid
PAPER Nelson PT, Head E, Schmitt FA, Davis PR, Neltner JH, Jicha GA, Abner EL, Smith CD, Van Eldik LJ, Kryscio RJ, Scheff SW
Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies.
Acta Neuropathol. 2011 May;121(5):571-87. PubMed: 21516511PAPER Schneider LS
Commentary on "Meta-analysis of six-month memantine trials in Alzheimer's disease." Wuthering forest plots: distinguishing the forest from the plots.
Alzheimers Dement. 2007 Jan;3(1):18-20. PubMed: 19595911Claudiu Bandea on Reimagining Alzheimer's Disease—Time for Bright New Ideas?
COMMENT Enticed by the topic and the title of this well-timed Alzforum Webinar, I would like to briefly present here a novel, unifying scenario on the nature of AD, PD, HD, ALS, FTLD-U, CJD, and other related devastating neurodegenerative disorders (1,2). Similar
CCR2-Positive Macrophages: White Knights of Phagocytes?
RESEARCH NEWS 2011-04-26 Research News Immune cells in the brain can act like good soldiers in the fight against Alzheimer’s disease, gobbling up Aβ and keeping the disease at bay. Or, they can stir up trouble by releasing harmful inflammatory cytokines. The line between the two
Is Manganese a Risk Factor for PD?
RESEARCH NEWS 2011-04-25 Research News No one knows exactly what causes sporadic Parkinson’s disease, but scientists know that both genetic and environmental risk factors contribute. One suspected environmental culprit is manganese, a metal often alloyed with steel to increase it
PAPER Bowler RM, Nakagawa S, Drezgic M, Roels HA, Park RM, Diamond E, Mergler D, Bouchard M, Bowler RP, Koller W
Sequelae of fume exposure in confined space welding: a neurological and neuropsychological case series.
Neurotoxicology. 2007 Mar;28(2):298-311. PubMed: 17169432PAPER RODIER J
Manganese poisoning in Moroccan miners.
Br J Ind Med. 1955 Jan;12(1):21-35. PubMed: 14351643Current Filters
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