COMMENT It is fascinating to follow this debate between the teams of De Strooper/Chávez-Gutiérrez and Shen/Kelleher. The technical arguments presented by both teams in the discussion sections of their recent papers in Neuron are valuable information. However, ...
COMMENT I am very interested in the debate on the pathological effects of PS1 inactive mutations. I rather agree that we should not underestimate the potential role of Aβ43 in the formation of Aβ aggregates. Aβ43 possibly acts as a seed to recruit other Aβ ...
COMMENT The present dispute concerns discrepancies between our finding that FAD-linked Psen1 knock-in (KI) mutations cause a loss of Aβ43 production in the adult mouse brain when mutant PS1 is expressed at normal levels and with the normal spatiotemporal pattern, ...
RESEARCH NEWS 2016-05-03 Research News Repeat expansions in the C9ORF72 gene increase risk for amyotrophic lateral sclerosis and frontotemporal dementia, but scientists have struggled to develop a mouse model that recapitulates the full spectrum of disease symptoms. In the April ...
Ludwig-Maximilians-University Munich and German Center for Neurodegenerative Diseases, MunichGermany
University of BordeauxBordeaux, France
AbbVieCambridge, United States
PAPER Gan-Or Z, Mohsin N, Girard SL, Montplaisir JY, Ambalavanan A, Strong S, Mallett V, Laurent SB, Bourassa CV, Boivin M, Langlois M, Arnulf I, Högl B, Frauscher B, Monaca C, Desautels A, Gagnon JF, Postuma RB, Dion PA, Dauvilliers Y, Dupre N, Alcalay RN, Rouleau GA27131830
PAPER Moon CM, Kim BC, Jeong GW
Effects of donepezil on brain morphometric and metabolic changes in patients with Alzheimer's disease: A DARTEL-based VBM and (1)H-MRS.Magn Reson Imaging. 2016 Apr 27; PubMed: 27131829
PAPER Qi L, Ke L, Liu X, Liao L, Ke S, Liu X, Wang Y, Lin X, Zhou Y, Wu L, Chen Z, Liu L
Subcutaneous administration of liraglutide ameliorates learning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3β pathway in an amyloid β protein induced alzheimer disease mouse model.Eur J Pharmacol. 2016 Apr 27; PubMed: 27131827
PAPER Xian YF, Ip SP, Mao QQ, Lin ZX
Neuroprotective effects of honokiol against beta-amyloid-induced neurotoxicity via GSK-3β and β-catenin signaling pathway in PC12 cells.Neurochem Int. 2016 Apr 27; PubMed: 27131736
PAPER Malm T, Loppi S, Kanninen KM27131734
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