PAPER Haruna Y, Kashihara N, Satoh M, Tomita N, Namikoshi T, Sasaki T, Fujimori T, Xie P, Kanwar YS

Amelioration of progressive renal injury by genetic manipulation of Klotho gene.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2331-6. Epub 2007 Feb 7 PubMed: 17287345

PAPER Kuro-o M

Klotho in chronic kidney disease--what's new?

Nephrol Dial Transplant. 2009 Jun;24(6):1705-8. Epub 2009 Feb 18 PubMed: 19225012

Diego Iacono on Neuropathologic assessment of dementia markers in identical and fraternal twins.

COMMENT What happens in two genetically identical brains after 98 years? What happens in the brains of two not genetically identical, but fraternal and opposite-sex twins after 79 years? What are the similarities and differences between two brains that at the beg

PAPER Park SJ, Shin EJ, Min SS, An J, Li Z, Hee Chung Y, Hoon Jeong J, Bach JH, Nah SY, Kim WK, Jang CG, Kim YS, Nabeshima Y, Nabeshima T, Kim HC

Inactivation of JAK2/STAT3 signaling axis and downregulation of M1 mAChR cause cognitive impairment in klotho mutant mice, a genetic model of aging.

Neuropsychopharmacology. 2013 Jul;38(8):1426-37. Epub 2013 Feb 6 PubMed: 23389690

PAPER Yang H, Fogo AB

Cell senescence in the aging kidney.

J Am Soc Nephrol. 2010 Sep;21(9):1436-9. Epub 2010 Aug 12 PubMed: 20705707

Mark Mattson on Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

COMMENT The new findings of Villeda et al. are remarkable and thought-provoking, as they suggest the possibility that transfusion of blood/plasma from young humans can restore cognitive function in patients with mild cognitive impairment or Alzheimer’s disease. I

Reports Weaken Death Receptor Link to Alzheimer's Disease

RESEARCH NEWS 2014-05-09 Research News [3 January 2024 Editor's note: The paper that prompted the follow-up investigation covered below has been RETRACTED.] Links between death receptor 6, a cell surface protein that triggers pruning of neuronal axons, and Alzheimer's d

PAPER Olsen O, Kallop DY, McLaughlin T, Huntwork-Rodriguez S, Wu Z, Duggan CD, Simon DJ, Lu Y, Easley-Neal C, Takeda K, Hass PE, Jaworski A, O'Leary DD, Weimer RM, Tessier-Lavigne M

Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase.

J Neurosci. 2014 May 7;34(19):6438-47. PubMed: 24806670

PAPER Kallop DY, Meilandt WJ, Gogineni A, Easley-Neal C, Wu T, Jubb AM, Yaylaoglu M, Shamloo M, Tessier-Lavigne M, Scearce-Levie K, Weimer RM

A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.

J Neurosci. 2014 May 7;34(19):6425-37. PubMed: 24806669

Jesus Avila on Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers.

COMMENT The authors have published a clear and well-performed study on the role of dendritic tau. Several years ago, the dogma was that tau is an intracellular, axonal protein. Now, we know about the multiple faces of tau. Tau could be inside or outside a neuron,

Heidi Jurgens

PAPER Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL

Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors.

Science. 2014 May 9;344(6184):630-4. Epub 2014 May 5 PubMed: 24797482

Longevity Gene Boosts Brainpower, Even in the Young

RESEARCH NEWS 2014-05-09 Research News Named after the Greek goddess who spins the thread of life, the klotho gene not only extends lifespan in mice and humans but also bestows greater intelligence, according to a paper published open-access in Cell Reports on May 8. Scientists l

PAPER Di Bona D, Accardi G, Virruso C, Candore G, Caruso C

Association of Klotho polymorphisms with healthy aging: a systematic review and meta-analysis.

Rejuvenation Res. 2014 Apr;17(2):212-6. Epub 2014 Apr 11 PubMed: 24164579

PAPER Eren M, Boe AE, Murphy SB, Place AT, Nagpal V, Morales-Nebreda L, Urich D, Quaggin SE, Budinger GR, Mutlu GM, Miyata T, Vaughan DE

PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):7090-5. Epub 2014 Apr 28 PubMed: 24778222