PAPER van Blitterswijk M, Landers JE
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Abraham Fisher on Deletion of M1 muscarinic acetylcholine receptors increases amyloid pathology in vitro and in vivo.
COMMENT The paper by Davis et al. adds further support to the major and pivotal role of the M1 muscarinic receptor (M1 AChR) in AD pathology and possible treatment with selective M1 agonists. It adds indirect support to our earlier findings that M1 agonists such
Anne Fagan on Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment.
COMMENT In their recent paper in Acta Neuropatholgica, Hu and colleagues investigated whether novel biomarkers (including those associated with inflammation, apoptosis, growth factor signaling, etc.), on their own or in combination with the established AD biomark
Andrew Quest on Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein.
COMMENT The study by Venkataramani et al., 2010 (1), supports findings from previous reports that implicate the β amyloid precursor protein (APP) as a crucial intermediate in the control of pancreatic and colon cancer cell growth. Interestingly, the amino termina
PAPER Roch JM, Masliah E, Roch-Levecq AC, Sundsmo MP, Otero DA, Veinbergs I, Saitoh T
Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor.
Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7450-4. PubMed: 8052602PAPER Sisodia SS