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Metabolomics Comes of Age

SERIES Move over, genome, transcriptome, proteome. The latest ome aims to map every metabolite linked to human health and disease. Metabolomics, although still a nascent field, offers hope for biomarkers and treatments in neurodegenerative disease. The field

Metabolomics: Seeking Biomarkers for ALS, Parkinson’s, Huntington’s

RESEARCH NEWS 2011-03-01 Research News Metabolomics—the sum of every small molecule linked to health or illness—is a young field (see Part 1 and Part 2), but it has already given researchers studying Alzheimer’s disease plenty to think about (see Part 3). Scientists studying othe

In Prion Disease, Toxicity Comes After Infection

RESEARCH NEWS 2011-03-01 Research News Scientists’ view of amyloid’s role in Alzheimer’s disease has evolved from the view that large amyloid fibrils poison the brain to one primarily blaming soluble, oligomeric forms of Aβ. A similar evolution of thought may be on the horizon fo

Viva La Vida: New Clues to Living Long and Healthy

RESEARCH NEWS 2011-03-01 Research News For creatures ranging from yeast to worms to mice, impaired growth hormone signaling restricts size but brings big benefits—longer life, and protection from age-related disease. Now, a 22-year longitudinal study confirms that some of these a

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