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Cheryl Wellington on ApoE4 Promotes Aβ Oligomerization

COMMENT Carriers of the detrimental ApoE4 genotype have long been hypothesized to have slower Aβ catabolism, leading to earlier onset and more amyloid burden than non-ApoE4 carriers. Critical questions involve defining the mechanisms by which ApoE4 leads to slugg

New Strategies for Early Diagnosis of AD

CONFERENCE COVERAGE 2012-10-26 Conference Coverage “Earlier” seems to be the new mantra in Alzheimer’s research. With biomarker data indicating that amyloid pathology begins up to 20 years before symptoms appear, many researchers now believe that treatment should start in the preclinic

Thousands of Whole Genomes to Be Mined for New Clues to AD

RESEARCH NEWS 2012-10-26 Research News With its ever-dropping price tag, whole-genome sequencing is taking off in Alzheimer's research. Several new collaborative projects aim to use this technology to more deeply understand Alzheimer's disease and find genetic clues to

ApoE4 Promotes Aβ Oligomerization

RESEARCH NEWS 2012-10-26 Research News How does apolipoprotein E (ApoE) boost risk for late-onset Alzheimer’s disease (LOAD)? While prior work suggests it accelerates amyloid-β deposition, a study in the October 24 Journal of Neuroscience examines how ApoE, the top LOAD risk gene

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