The Jackson Laboratory
University of WarwickCoventry, United Kingdom
Crystal Brook, Australia
Hope Island, Australia
COMMENT The reported premature halt of the BACE inhibitor is a substantial setback, as the field desperately needs some success. Obviously, we need to scrutinize the clinical data in more detail before we can identify possible reasons. However, together with the ...
CONFERENCE 2017-04-04 00:00:00-2017-04-08 00:00:00 Cold Spring Harbor, New York 04 – 08 April 2017 View Conference Website 1 ...
COMMENT Let us hope that prodromal AD will benefit from verubecestat treatment. A problem with even this relatively early stage of disease is that Aβ may have already accumulated, which will make a negative study difficult to interpret. This confound is in ...
Bruce Lamb, Paul Territo, Greg Carter, Gareth Howell on Building Better Mouse Models for Late-Onset Alzheimer’s
COMMENT We thank Dr. Geerts for his comments regarding the MODEL-AD project. We also agree with his assessment regarding the importance of linking preclinical models to “accessible and measurable objective biomarkers (plasma, CSF, as well as RNA-Seq and brain ...
Shiley-Marcos Alzheimer's Disease Research CenterLa Jolla, United States
Haut CapitalConcord, United States
Institute for the Study of Culturogenic DiseasePahoa, United States
Toxicology and biochimistryAlgeria
COMMENT By definition, large studies like these are inherently limited to very simple measurements. In this study, something as physiologically complex as sleep is reduced to participants ticking a single box as part of a larger general questionnaire at two ...
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