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PAPER Qin J, Zhou W, Huang X, Dhondi P, Palani A, Aslanian R, Zhu Z, Greenlee W, Cohen-Williams M, Jones N, Hyde L, Zhang L
Discovery of a Potent Pyrazolopyridine Series of γ-Secretase Modulators.
ACS Med Chem Lett. 2011 Jun 9;2(6):471-6. Epub 2011 Mar 29 PubMed: 24900332PAPER Peng H, Talreja T, Xin Z, Cuervo JH, Kumaravel G, Humora MJ, Xu L, Rohde E, Gan L, Jung MY, Shackett MN, Chollate S, Dunah AW, Snodgrass-Belt PA, Arnold HM, Taveras AG, Rhodes KJ, Scannevin RH
Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator.
ACS Med Chem Lett. 2011 Oct 13;2(10):786-91. Epub 2011 Aug 5 PubMed: 24900267PAPER Huang X, Aslanian R, Zhou W, Zhu X, Qin J, Greenlee W, Zhu Z, Zhang L, Hyde L, Chu I, Cohen-Williams M, Palani A
The Discovery of Pyridone and Pyridazone Heterocycles as γ-Secretase Modulators.
ACS Med Chem Lett. 2010 Jul 8;1(4):184-7. Epub 2010 May 24 PubMed: 24900193PAPER Gillman KW Jr, Starrett JE Jr, Parker MF, Xie K, Bronson JJ, Marcin LR, McElhone KE, Bergstrom CP, Mate RA, Williams R, Meredith JE, Burton CR, Barten DM, Toyn JH, Roberts SB, Lentz KA, Houston JG, Zaczek R, Albright CF, Decicco CP, Macor JE, Olson RE
Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor.
ACS Med Chem Lett. 2010 Jun 10;1(3):120-4. Epub 2010 Mar 22 PubMed: 24900185PAPER Zarbiv Y, Simhi-Haham D, Israeli E, Elhadi SA, Grigoletto J, Sharon R
Lysine residues at the first and second KTKEGV repeats mediate α-Synuclein binding to membrane phospholipids.
Neurobiol Dis. 2014 Oct;70:90-8. Epub 2014 Jun 4 PubMed: 24905915PAPER Schöndorf DC, Aureli M, McAllister FE, Hindley CJ, Mayer F, Schmid B, Sardi SP, Valsecchi M, Hoffmann S, Schwarz LK, Hedrich U, Berg D, Shihabuddin LS, Hu J, Pruszak J, Gygi SP, Sonnino S, Gasser T, Deleidi M
iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis.
Nat Commun. 2014 Jun 6;5:4028. PubMed: 24905578PAPER Chege PM, McColl G
Caenorhabditis elegans: a model to investigate oxidative stress and metal dyshomeostasis in Parkinson's disease.
Front Aging Neurosci. 2014;6:89. Epub 2014 May 19 PubMed: 24904406PAPER Ariga T
Pathogenic role of ganglioside metabolism in neurodegenerative diseases.
J Neurosci Res. 2014 Oct;92(10):1227-42. Epub 2014 Jun 5 PubMed: 24903509PAPER Nassif M, Valenzuela V, Rojas-Rivera D, Vidal R, Matus S, Castillo K, Fuentealba Y, Kroemer G, Levine B, Hetz C
Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis.
Autophagy. 2014 Jul;10(7):1256-71. Epub 2014 May 12 PubMed: 24905722PAPER Matus S, Medinas DB, Hetz C
Common ground: stem cell approaches find shared pathways underlying ALS.
Cell Stem Cell. 2014 Jun 5;14(6):697-9. PubMed: 24905158PAPER Cecchi M, Messina P, Airoldi L, Pupillo E, Bandettini di Poggio M, Calvo A, Filosto M, Lunetta C, Mandrioli J, Pisa F, Pastorelli R, Beghi E, EURALS Consortium
Plasma amino acids patterns and age of onset of amyotrophic lateral sclerosis.
Amyotroph Lateral Scler Frontotemporal Degener. 2014 Sep;15(5-6):371-5. Epub 2014 Jun 6 PubMed: 24904978PAPER Maximino JR, de Oliveira GP, Alves CJ, Chadi G
Deregulated expression of cytoskeleton related genes in the spinal cord and sciatic nerve of presymptomatic SOD1(G93A) Amyotrophic Lateral Sclerosis mouse model.
Front Cell Neurosci. 2014;8:148. Epub 2014 May 26 PubMed: 24904291PAPER Brites D, Vaz AR
Microglia centered pathogenesis in ALS: insights in cell interconnectivity.
Front Cell Neurosci. 2014;8:117. Epub 2014 May 22 PubMed: 24904276PAPER Li W, Antuono PG, Xie C, Chen G, Jones JL, Ward BD, Singh SP, Franczak MB, Goveas JS, Li SJ
Aberrant functional connectivity in Papez circuit correlates with memory performance in cognitively intact middle-aged APOE4 carriers.
Cortex. 2014 Aug;57:167-76. Epub 2014 Apr 30 PubMed: 24905971Current Filters
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