PAPER Lange DJ, Felice KJ, Festoff BW, Gawel MJ, Gelinas DF, Kratz R, Lai EC, Murphy MF, Natter HM, Norris FH, Rudnicki S

Recombinant human insulin-like growth factor-I in ALS: description of a double-blind, placebo-controlled study. North American ALS/IGF-I Study Group.

Neurology. 1996 Oct;47(4 Suppl 2):S93-4; discussion S94-5. PubMed: 8858058

PAPER

A controlled trial of recombinant methionyl human BDNF in ALS: The BDNF Study Group (Phase III).

Neurology. 1999 Apr 22;52(7):1505-7. PubMed: 10227630

PAPER

A phase I study of recombinant human ciliary neurotrophic factor (rHCNTF) in patients with amyotrophic lateral sclerosis. The ALS CNTF Treatment Study (ACTS) Phase I-II Study Group.

No To Shinkei. 1996 Apr;48(4):333-44. PubMed: 8681312

Theodore VanItallie

Columbia University College of Physiciahns & Surgeons
Old Lyme, United States

Takaomi Saido on A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease.

COMMENT This is indirect evidence for the role of tau phosphorylation in the cognitive deficit in AD. 0 saido

Takaomi Saido on Amyloid-β associated volume loss occurs only in the presence of phospho-tau.

COMMENT A very informative study. One question is, Does the phosphorylation status of CSF tau reflect that of intraneuronal tau? 0 saido

PAPER Morishita H, Hensch TK

Critical period revisited: impact on vision.

Curr Opin Neurobiol. 2008 Feb;18(1):101-7. PubMed: 18534841

PAPER Morishita H, Miwa JM, Heintz N, Hensch TK

Lynx1, a cholinergic brake, limits plasticity in adult visual cortex.

Science. 2010 Nov 26;330(6008):1238-40. PubMed: 21071629

Orly Lazarov on Novel Techniques Test Newborn Neurons' Role in Memory

COMMENT Loss of memory trace-linked, postnatally born neurons has important implications for understanding the role of adult neurogenesis in normal and neuropathological age-related cognitive decline. It would be important to establish whether in Alzheimer's

Peter Kjall

Karolinska Institutet
Stockholm, Sweden

Jee Hoon Roh

Washington University School of Medicine
St. Louis, United States

PAPER Sultan S, Rey N, Sacquet J, Mandairon N, Didier A

Newborn neurons in the olfactory bulb selected for long-term survival through olfactory learning are prematurely suppressed when the olfactory memory is erased.

J Neurosci. 2011 Oct 19;31(42):14893-8. PubMed: 22016522

PAPER Duque A, Rakic P

Different effects of bromodeoxyuridine and [3H]thymidine incorporation into DNA on cell proliferation, position, and fate.

J Neurosci. 2011 Oct 19;31(42):15205-17. PubMed: 22016554

Takaomi Saido on Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration.

COMMENT An important paper. 0 saido

Put Nerves Under Ion Control, and Activation Is Yours

RESEARCH NEWS 2011-10-24 Research News Sodium ions wait outside neurons like knights raring to storm the keep. Man the gates and you can control the castle, or in the case of a neuron, its action potential. However, existing electrical methods require potentially dangerous curren