Does Shrinking Temporal Lobe Make AD Patients Overly Sensitive?

RESEARCH NEWS 2013-05-31 Research News Though typically seen as a cognitive disorder, Alzheimer’s disease can throw emotions off kilter, making people unusually sensitive to others’ feelings and moods. New research suggests biological underpinnings for such changes. A report in t

PAPER Hayakawa H, Nagai M, Kawanami A, Nakata Y, Nihira T, Ogino M, Takada M, Saido T, Takano J, Saegusa M, Mikami T, Hamada J, Nishiyama K, Mochizuki H, Mizuno Y

Loss of DARPP-32 and calbindin in multiple system atrophy.

J Neural Transm. 2013 May 29; PubMed: 23715974

PAPER Liu W, Yamashita T, Tian F, Morimoto N, Ikeda Y, Deguchi K, Abe K

Mitochondrial fusion and fission proteins expression dynamically change in a murine model of amyotrophic lateral sclerosis.

Curr Neurovasc Res. 2013 Jul 30;10(3):222-30. PubMed: 23713734

PAPER Tong J, Huang C, Bi F, Wu Q, Huang B, Liu X, Li F, Zhou H, Xia XG

Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats.

EMBO J. 2013 Jul 3;32(13):1917-26. PubMed: 23714777

PAPER Soreq L, Salomonis N, Bronstein M, Greenberg DS, Israel Z, Bergman H, Soreq H

Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes.

Front Mol Neurosci. 2013;6:10. PubMed: 23717260

PAPER Decressac M, Björklund A

TFEB: Pathogenic role and therapeutic target in Parkinson disease.

Autophagy. 2013 Aug 1;9(8):1244-6. PubMed: 23715007

PAPER Sacino AN, Thomas MA, Ceballos-Diaz C, Cruz PE, Rosario AM, Lewis J, Giasson BI, Golde TE

Conformational templating of α-synuclein aggregates in neuronal-glial cultures.

Mol Neurodegener. 2013;8:17. PubMed: 23714769

PAPER Yan LM, Velkova A, Kapurniotu A

Molecular Characterization of the Hetero-Assembly of β-Amyloid Peptide with Islet Amyloid Polypeptide.

Curr Pharm Des. 2013 May 22; PubMed: 23713771

PAPER Nakajima A, Aoyama Y, Nguyen TT, Shin EJ, Kim HC, Yamada S, Nakai T, Nagai T, Yokosuka A, Mimaki Y, Ohizumi Y, Yamada K

Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse.

Behav Brain Res. 2013 Aug 1;250:351-60. PubMed: 23714077

PAPER Barulli DJ, Rakitin BC, Lemaire P, Stern Y

The influence of cognitive reserve on strategy selection in normal aging.

J Int Neuropsychol Soc. 2013 Aug;19(7):841-4. PubMed: 23714237

PAPER Mawuenyega KG, Kasten T, Sigurdson W, Bateman RJ

Amyloid-beta isoform metabolism quantitation by stable isotope-labeled kinetics.

Anal Biochem. 2013 Sep 1;440(1):56-62. PubMed: 23714261

PAPER Chiatti C, Masera F, Rimland JM, Cherubini A, Scarpino O, Spazzafumo L, Lattanzio F,

The UP-TECH project, an intervention to support caregivers of Alzheimer's disease patients in Italy: study protocol for a randomized controlled trial.

Trials. 2013;14:155. PubMed: 23714287

PAPER Ho CY, Troncoso JC, Knox D, Stark W, Eberhart CG

Beta-Amyloid, Phospho-Tau and Alpha-Synuclein Deposits Similar to Those in the Brain Are Not Identified in the Eyes of Alzheimer's and Parkinson's Disease Patients.

Brain Pathol. 2013 May 29; PubMed: 23714377

PAPER Bignante EA, Heredia F, Morfini G, Lorenzo A

Amyloid β precursor protein as a molecular target for amyloid β-induced neuronal degeneration in Alzheimer's disease.

Neurobiol Aging. 2013 Nov;34(11):2525-37. PubMed: 23714735

PAPER Merino-Serrais P, Benavides-Piccione R, Blazquez-Llorca L, Kastanauskaite A, Rábano A, Avila J, Defelipe J

The influence of phospho-τ on dendritic spines of cortical pyramidal neurons in patients with Alzheimer's disease.

Brain. 2013 Jun;136(Pt 6):1913-28. PubMed: 23715095