COMMENT The research conducted by Dr. Saido and his colleagues is long overdue, relevant, and gets to the heart of the problem of using overexpressing APP models. There is now sufficient data to indicate the neurotropic properties of APP and Aβ and why strategies ...
COMMENT I read with considerable interest the paper of Saido and colleagues describing the lack of calpain activation, p25 accumulation, and tau pathology in their mutant APP knock-in mouse line. Relevant to the discussion surrounding the validity of these ...
COMMENT Excellent story on NIA's Division of Neuroscience and a great profile on Eliezer and his vision for the future of AD research funding. I point out two references, below, regarding the the early history of "program development" on brain ...
PAPER Khachaturian ZS
A chapter in the development of Alzheimer's disease research: a case study of public policies on the development and funding of research programs.Alzheimers Dement. 2007 Jul;3(3):243-58. PubMed: 19595945
COMMENT I agree with Drs. Ashe and Sasner that the field needs better models that more closely recapitulate AD phenotypes. I am optimistic that the next generation of AD models will be greatly facilitated by the recently developed genome-editing technologies. For ...
PAPER Su SC, Rudenko A, Cho S, Tsai LH
Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment.Neurobiol Learn Mem. 2013 Oct;105:54-62. Epub 2013 Jul 11 PubMed: 23850563
Washington University School of MedicineSaint Louis, United States
PAPER Maurer, Maurer
University of Minnesota - Twin CitiesMinneapolis, United States
PAPER Eleti S
Drugs in Alzheimer's disease Dementia: An overview of current pharmacological management and future directions.Psychiatr Danub. 2016 Sep;28(Suppl-1):136-140. PubMed: 27663824
PAPER Karikari TK, Turner A, Stass R, Lee LC, Wilson B, Nagel DA, Hill EJ, Moffat KG
Expression and purification of tau protein and its frontotemporal dementia variants using a cleavable histidine tag.Protein Expr Purif. 2016 Sep 20; PubMed: 27663563
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